Abstract
The purpose of this study was to assess tendon metabolism and suture pull-out strength after simple tendon suture in a tissue culture model. One hundred and twelve flexor digitorum profundus tendons from 28 dogs were cultured for 7, 14, or 21 days with or without a static tensile load. In both groups increased levels of matrix metalloproteinase (MMP) mRNA was noted. Suture pull-out strength did not decrease during tissue culture. While the presence of a static load had no effect on the pull-out strength, it did affect MMP mRNA expression. This tissue culture model could be useful in studying the effect of factors on the tendon-suture interface.
Original language | English (US) |
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Pages (from-to) | 643-650 |
Number of pages | 8 |
Journal | Journal of Hand Surgery: European Volume |
Volume | 34 |
Issue number | 5 |
DOIs | |
State | Published - 2009 |
Keywords
- Matrix metalloproteinases
- Suture strength
- Tendon repair
- Tissue culture
ASJC Scopus subject areas
- Surgery