The effect of tissue culture on suture holding strength and degradation in canine tendon

H. Omae, Chunfeng Zhao, Y. L. Sun, M. E. Zobitz, S. L. Moran, P. C. Amadio

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The purpose of this study was to assess tendon metabolism and suture pull-out strength after simple tendon suture in a tissue culture model. One hundred and twelve flexor digitorum profundus tendons from 28 dogs were cultured for 7, 14, or 21 days with or without a static tensile load. In both groups increased levels of matrix metalloproteinase (MMP) mRNA was noted. Suture pull-out strength did not decrease during tissue culture. While the presence of a static load had no effect on the pull-out strength, it did affect MMP mRNA expression. This tissue culture model could be useful in studying the effect of factors on the tendon-suture interface.

Original languageEnglish (US)
Pages (from-to)643-650
Number of pages8
JournalJournal of Hand Surgery: European Volume
Volume34
Issue number5
DOIs
StatePublished - Nov 25 2009

Keywords

  • Matrix metalloproteinases
  • Suture strength
  • Tendon repair
  • Tissue culture

ASJC Scopus subject areas

  • Surgery

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