The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment

R. Scott Mackin, Philip Insel, Duygu Tosun, Susanne G. Mueller, Norbert Schuff, Diana Truran-Sacrey, Sky T. Raptentsetsang, Jun Young Lee, Clifford R Jr. Jack, Paul S. Aisen, Ronald Carl Petersen, Michael W. Weiner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To assess the effect of subsyndromalsymptomsof depression (SSD) onratings of disability for individualswith mild cognitive impairment (MCI). Methods: Data from 405 MCI participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were analyzed. Participants were evaluated at baseline and at 6-month intervals over 2 years. Severity of depressive symptoms was rated utilizing the Geriatric Depression Scale. Disability was assessed utilizing the Functional Assessment Questionnaire (FAQ). Other clinical variables included white matter lesion (WML) and intracranial brain (ICV) volumes derived from magnetic resonance imaging, ratings of overall cognitive function (Alzheimer's Disease Assessment Scale, ADAS), and apolipoprotein E (ApoE) status. Demographic variables included age, education, and gender. Results: SSD individuals had a lower volume of WML and higher frequency of ApoE ε4 alleles than nondepressed participants but the two groups did not differwith respect to other clinical or demographic variables. At baseline, SSD individuals were 1.77 times more likely to have poorer FAQ scores than individuals with no symptoms of depression after controlling for the effect of cognitive functioning, ICV, WML, and ApoE status. The presence of SSD at baseline was not associated with a poorer course of disability outcomes, cognitive functioning, or conversion to dementia over 24 months. Conclusions: SSD demonstrated a significant impact on disability for MCI individuals, who are also at high risk for functional limitations related to neurodegenerative disease. Therefore, the treatment of SSD may represent a significant avenue to reduce the burden of disability in this vulnerable patient population.

Original languageEnglish (US)
Pages (from-to)906-914
Number of pages9
JournalAmerican Journal of Geriatric Psychiatry
Volume21
Issue number9
DOIs
StatePublished - Sep 2013

Fingerprint

Depression
Apolipoproteins E
Alzheimer Disease
Demography
Apolipoprotein E4
White Matter
Cognitive Dysfunction
Vulnerable Populations
Neuroimaging
Geriatrics
Neurodegenerative Diseases
Cognition
Dementia
Alleles
Magnetic Resonance Imaging
Education
Brain

Keywords

  • ApoE
  • Dementia
  • Disability
  • Longitudinal
  • Mild cognitive impairment
  • Subsyndromal depression
  • Subthreshold depression
  • White matter lesions

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. / Mackin, R. Scott; Insel, Philip; Tosun, Duygu; Mueller, Susanne G.; Schuff, Norbert; Truran-Sacrey, Diana; Raptentsetsang, Sky T.; Lee, Jun Young; Jack, Clifford R Jr.; Aisen, Paul S.; Petersen, Ronald Carl; Weiner, Michael W.

In: American Journal of Geriatric Psychiatry, Vol. 21, No. 9, 09.2013, p. 906-914.

Research output: Contribution to journalArticle

Mackin, RS, Insel, P, Tosun, D, Mueller, SG, Schuff, N, Truran-Sacrey, D, Raptentsetsang, ST, Lee, JY, Jack, CRJ, Aisen, PS, Petersen, RC & Weiner, MW 2013, 'The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment', American Journal of Geriatric Psychiatry, vol. 21, no. 9, pp. 906-914. https://doi.org/10.1016/j.jagp.2013.01.021
Mackin, R. Scott ; Insel, Philip ; Tosun, Duygu ; Mueller, Susanne G. ; Schuff, Norbert ; Truran-Sacrey, Diana ; Raptentsetsang, Sky T. ; Lee, Jun Young ; Jack, Clifford R Jr. ; Aisen, Paul S. ; Petersen, Ronald Carl ; Weiner, Michael W. / The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. In: American Journal of Geriatric Psychiatry. 2013 ; Vol. 21, No. 9. pp. 906-914.
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AU - Lee, Jun Young

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AU - Aisen, Paul S.

AU - Petersen, Ronald Carl

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