The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment

R. Scott Mackin, Philip Insel, Duygu Tosun, Susanne G. Mueller, Norbert Schuff, Diana Truran-Sacrey, Sky T. Raptentsetsang, Jun Young Lee, Clifford R. Jack, Paul S. Aisen, Ronald C. Petersen, Michael W. Weiner

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To assess the effect of subsyndromal symptoms of depression (SSD) on ratings of disability for individuals with mild cognitive impairment (MCI). METHODS: Data from 405 MCI participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were analyzed. Participants were evaluated at baseline and at 6-month intervals over 2 years. Severity of depressive symptoms was rated utilizing the Geriatric Depression Scale. Disability was assessed utilizing the Functional Assessment Questionnaire (FAQ). Other clinical variables included white matter lesion (WML) and intracranial brain (ICV) volumes derived from magnetic resonance imaging, ratings of overall cognitive function (Alzheimer's Disease Assessment Scale, ADAS), and apolipoprotein E (ApoE) status. Demographic variables included age, education, and gender. RESULTS: SSD individuals had a lower volume of WML and higher frequency of ApoE [Latin Small Letter Open E]4 alleles than nondepressed participants but the two groups did not differ with respect to other clinical or demographic variables. At baseline, SSD individuals were 1.77 times more likely to have poorer FAQ scores than individuals with no symptoms of depression after controlling for the effect of cognitive functioning, ICV, WML, and ApoE status. The presence of SSD at baseline was not associated with a poorer course of disability outcomes, cognitive functioning, or conversion to dementia over 24 months. CONCLUSIONS: SSD demonstrated a significant impact on disability for MCI individuals, who are also at high risk for functional limitations related to neurodegenerative disease. Therefore, the treatment of SSD may represent a significant avenue to reduce the burden of disability in this vulnerable patient population.

Original languageEnglish (US)
JournalAmerican Journal of Geriatric Psychiatry
DOIs
StateAccepted/In press - Sep 26 2012
Externally publishedYes

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Depression
Apolipoproteins E
Alzheimer Disease
Demography
White Matter
Cognitive Dysfunction
Vulnerable Populations
Neuroimaging
Geriatrics
Neurodegenerative Diseases
Cognition
Dementia
Alleles
Magnetic Resonance Imaging
Education
Brain

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. / Scott Mackin, R.; Insel, Philip; Tosun, Duygu; Mueller, Susanne G.; Schuff, Norbert; Truran-Sacrey, Diana; Raptentsetsang, Sky T.; Lee, Jun Young; Jack, Clifford R.; Aisen, Paul S.; Petersen, Ronald C.; Weiner, Michael W.

In: American Journal of Geriatric Psychiatry, 26.09.2012.

Research output: Contribution to journalArticle

Scott Mackin, R. ; Insel, Philip ; Tosun, Duygu ; Mueller, Susanne G. ; Schuff, Norbert ; Truran-Sacrey, Diana ; Raptentsetsang, Sky T. ; Lee, Jun Young ; Jack, Clifford R. ; Aisen, Paul S. ; Petersen, Ronald C. ; Weiner, Michael W. / The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. In: American Journal of Geriatric Psychiatry. 2012.
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AU - Schuff, Norbert

AU - Truran-Sacrey, Diana

AU - Raptentsetsang, Sky T.

AU - Lee, Jun Young

AU - Jack, Clifford R.

AU - Aisen, Paul S.

AU - Petersen, Ronald C.

AU - Weiner, Michael W.

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