The effect of raised inspired carbon dioxide on normal retinal vascular development in the neonatal rat

Jonathan M. Holmes, David A. Leske, Shuichen Zhang

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Purpose. Raised arterial carbon dioxide levels have been suggested as a risk factor for retinopathy of prematurity (ROP). We investigated the effect of raised inspired CO2 on normal postnatal vasculogenesis in the neonatal rat retina. Methods. One hundred fifty newborn rat pups were divided among 15 mothers (n = 10 for each litter). Five litters were exposed to low CO2 (0.2%), 5 litters exposed to 6%, and 5 litters to 10% CO2. On day 7 of life the rats were sacrificed and the total retinal and vascularized retinal areas analyzed. Results. The vascularized retinal area and ratio of vascularized to total retinal area were reduced in rats exposed to 6% and 10% CO2. Conclusions. Raised inspired CO2 was associated with retardation of normal retinal vascular development and increased peripheral avascular area in neonatal rats. Raised CO2 may be a risk factor for the development of abnormal neovascularization such as in ROP.

Original languageEnglish (US)
Pages (from-to)78-81
Number of pages4
JournalCurrent Eye Research
Volume16
Issue number1
DOIs
StatePublished - Mar 3 1997

Keywords

  • Carbon dioxide
  • Development
  • Rats
  • Retina
  • Vasculature

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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