TY - JOUR
T1 - The effect of polyp location and patient gender on the presence of dysplasia in colonic polyps
AU - Qumseya, Bashar J.
AU - Coe, Susan
AU - Wallace, Michael B.
N1 - Funding Information:
Guarantor of the article: Michael B. Wallace, MD. Specific author contributions: Study concept and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content, statistical analysis: Bashar J. Qumseya; acquisition of data, drafting of the manuscript: Susan Coe; study concept and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content, statistical analysis, and study supervision: Michael B. Wallace. Financial support: None. Potential competing interests: Dr Wallace is a consultant for Ninepoint Medical. He receives research funding from Olympus America, Inc., American BioOPTICS, and Fujinon.
PY - 2012
Y1 - 2012
N2 - Objective: There is increasing evidence of significant clinical and biological differences between proximal and distal colorectal polyps, as well as possible differences based on patient gender. There is a need to optimize and individualize screening strategies. We studied the potential influence of gender and of polyp location on the presence of dysplasia in colon polyps. Methods: We used a prospective database on adenoma detection to identify patients. The primary outcome was the presence of dysplasia in colonic polyps. Covariates include age, gender, race, lesion size and site, and use of aspirin. Multivariate logistic regression analysis was used to analyze the relationship between the primary outcome and covariates. Results were reported as odds ratios (ORs), 95% confidence intervals (CIs), and P-values. Results: A total of 2,400 patients (50.5% females and 49.5% males) completed colonoscopy for various indications. A total of 3,045 polyps were removed in 1,237 patients. Of those polyps, 54% (n=1,636) were on the right compared with 46% (n=1,409) in the left colon. The proportion of adenomas was significantly greater on the right colon when compared with the left: 69.4% vs. 39.3% (P= <0.0001). Multivariate logistic regression analysis showed that the right colon did have a significant association with dysplasia when controlling for age, gender, polyp size, and use of aspirin (OR=3.1 (95% CI: 2.3-4), P= <0.0001). Female gender was associated with decreased odds of finding dysplasia (OR=0.6 (95% CI: 0.46-0.78), P=0.03). Conclusion: Patient characteristics (male gender) as well procedure findings (increase polyp size and right-sided lesions) are associated with increased odds of dysplasia.
AB - Objective: There is increasing evidence of significant clinical and biological differences between proximal and distal colorectal polyps, as well as possible differences based on patient gender. There is a need to optimize and individualize screening strategies. We studied the potential influence of gender and of polyp location on the presence of dysplasia in colon polyps. Methods: We used a prospective database on adenoma detection to identify patients. The primary outcome was the presence of dysplasia in colonic polyps. Covariates include age, gender, race, lesion size and site, and use of aspirin. Multivariate logistic regression analysis was used to analyze the relationship between the primary outcome and covariates. Results were reported as odds ratios (ORs), 95% confidence intervals (CIs), and P-values. Results: A total of 2,400 patients (50.5% females and 49.5% males) completed colonoscopy for various indications. A total of 3,045 polyps were removed in 1,237 patients. Of those polyps, 54% (n=1,636) were on the right compared with 46% (n=1,409) in the left colon. The proportion of adenomas was significantly greater on the right colon when compared with the left: 69.4% vs. 39.3% (P= <0.0001). Multivariate logistic regression analysis showed that the right colon did have a significant association with dysplasia when controlling for age, gender, polyp size, and use of aspirin (OR=3.1 (95% CI: 2.3-4), P= <0.0001). Female gender was associated with decreased odds of finding dysplasia (OR=0.6 (95% CI: 0.46-0.78), P=0.03). Conclusion: Patient characteristics (male gender) as well procedure findings (increase polyp size and right-sided lesions) are associated with increased odds of dysplasia.
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U2 - 10.1038/ctg.2012.14
DO - 10.1038/ctg.2012.14
M3 - Article
C2 - 23238292
AN - SCOPUS:84864450650
SN - 2155-384X
VL - 3
JO - Clinical and translational gastroenterology
JF - Clinical and translational gastroenterology
M1 - e20
ER -