The effect of low- and high-velocity tendon excursion on the mechanical properties of human cadaver subsynovial connective tissue

Anika Filius, Andrew R. Thoreson, Tai Hua Yang, Matthias Vanhees, Kai Nan An, Chunfeng D Zhao, Peter C Amadio

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

SUMMARY Fibrosis of the subsynovial connective tissue (SSCT) in the carpal tunnel is the most common histological finding in carpal tunnel syndrome (CTS). Fibrosis may result from damaged SSCT. Previous studies found that with low-velocity (2 mm/s), tendon excursions can irreversibly damage the SSCT. We investigated the effect of tendon excursion velocity in the generation of SSCT damage. Nine human cadaver wrists were used. Three repeated cycles of ramp-stretch testing were performed simulating 40%, 60%, 90%, and 120% of the middle finger flexor tendon superficialis physiological excursion with an excursion velocity of 60 mm/s. Energy and force were calculated and normalized by values obtained in the first cycle for each excursion level. Data were compared with low-velocity excursion data. For high-velocity excursions, a significant drop in the excursion energy ratio was first observed at an excursion level of 60% physiological excursion (p < 0.024) and that for low-velocity excursions was first observed at 90% physiological excursion (p < 0.038). Furthermore, the energy ratio was lower at 60% for high velocities (p ≤ 0.039). Increasing velocity lowers the SSCT damage threshold. This finding may be relevant for understanding the pathogenesis of SSCT fibrosis, such as that accompanying CTS, and a relationship with occupational factors.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalJournal of Orthopaedic Research
Volume32
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Cadaver
Tendons
Connective Tissue
Fibrosis
Carpal Tunnel Syndrome
Wrist
Architectural Accessibility
Fingers

Keywords

  • biomechanics
  • carpal tunnel
  • human cadaver
  • subsynovial connective tissue
  • velocity

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

The effect of low- and high-velocity tendon excursion on the mechanical properties of human cadaver subsynovial connective tissue. / Filius, Anika; Thoreson, Andrew R.; Yang, Tai Hua; Vanhees, Matthias; An, Kai Nan; Zhao, Chunfeng D; Amadio, Peter C.

In: Journal of Orthopaedic Research, Vol. 32, No. 1, 01.2014, p. 123-128.

Research output: Contribution to journalArticle

Filius, Anika ; Thoreson, Andrew R. ; Yang, Tai Hua ; Vanhees, Matthias ; An, Kai Nan ; Zhao, Chunfeng D ; Amadio, Peter C. / The effect of low- and high-velocity tendon excursion on the mechanical properties of human cadaver subsynovial connective tissue. In: Journal of Orthopaedic Research. 2014 ; Vol. 32, No. 1. pp. 123-128.
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N2 - SUMMARY Fibrosis of the subsynovial connective tissue (SSCT) in the carpal tunnel is the most common histological finding in carpal tunnel syndrome (CTS). Fibrosis may result from damaged SSCT. Previous studies found that with low-velocity (2 mm/s), tendon excursions can irreversibly damage the SSCT. We investigated the effect of tendon excursion velocity in the generation of SSCT damage. Nine human cadaver wrists were used. Three repeated cycles of ramp-stretch testing were performed simulating 40%, 60%, 90%, and 120% of the middle finger flexor tendon superficialis physiological excursion with an excursion velocity of 60 mm/s. Energy and force were calculated and normalized by values obtained in the first cycle for each excursion level. Data were compared with low-velocity excursion data. For high-velocity excursions, a significant drop in the excursion energy ratio was first observed at an excursion level of 60% physiological excursion (p < 0.024) and that for low-velocity excursions was first observed at 90% physiological excursion (p < 0.038). Furthermore, the energy ratio was lower at 60% for high velocities (p ≤ 0.039). Increasing velocity lowers the SSCT damage threshold. This finding may be relevant for understanding the pathogenesis of SSCT fibrosis, such as that accompanying CTS, and a relationship with occupational factors.

AB - SUMMARY Fibrosis of the subsynovial connective tissue (SSCT) in the carpal tunnel is the most common histological finding in carpal tunnel syndrome (CTS). Fibrosis may result from damaged SSCT. Previous studies found that with low-velocity (2 mm/s), tendon excursions can irreversibly damage the SSCT. We investigated the effect of tendon excursion velocity in the generation of SSCT damage. Nine human cadaver wrists were used. Three repeated cycles of ramp-stretch testing were performed simulating 40%, 60%, 90%, and 120% of the middle finger flexor tendon superficialis physiological excursion with an excursion velocity of 60 mm/s. Energy and force were calculated and normalized by values obtained in the first cycle for each excursion level. Data were compared with low-velocity excursion data. For high-velocity excursions, a significant drop in the excursion energy ratio was first observed at an excursion level of 60% physiological excursion (p < 0.024) and that for low-velocity excursions was first observed at 90% physiological excursion (p < 0.038). Furthermore, the energy ratio was lower at 60% for high velocities (p ≤ 0.039). Increasing velocity lowers the SSCT damage threshold. This finding may be relevant for understanding the pathogenesis of SSCT fibrosis, such as that accompanying CTS, and a relationship with occupational factors.

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