The effect of long-term opiate antagonist administration to pubertal boys

H. E. Kulin, L. M. Demers, A. D. Rogol, Johannes D Veldhuis

Research output: Contribution to journalArticle

9 Scopus citations


To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15 were given the long-acting opiate antagonist, naltrexone, for up to 4 weeks. Urinary gonadotropin measurements were assessed before, during, and after drug administration. In three early to mid-pubertal boys who received naltrexone for 3 to 4 weeks, LRH testing was also performed. No evidence of a stimulatory FSH or LH response to naltrexone was found in any of the patients evaluated. The data do not support the operation of an opiate-mediated mechanism in the control of pubertal onset in man.

Original languageEnglish (US)
Pages (from-to)374-377
Number of pages4
JournalJournal of Andrology
Issue number6
StatePublished - 1987
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology

Cite this

Kulin, H. E., Demers, L. M., Rogol, A. D., & Veldhuis, J. D. (1987). The effect of long-term opiate antagonist administration to pubertal boys. Journal of Andrology, 8(6), 374-377.