The effect of hyperbaric oxygen on acute experimental sulfide poisoning in the rat

N. Bitterman, Y. Talmi, Amir Lerman, Y. Melamed, U. Taitelman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In order to evaluate the efficiency of hyperbaric oxygen in experimental acute sulfide poisoning, we studied the effect of 1 ATA (atmosphere absolute) oxygen and sodium nitrite therapy. We then studied the effect of oxygen at 3 ATA alone and in combination with intraperitoneal sodium nitrite injection on rats poisoned by intraperitoneal injection of LD75 sulfide. Electroencephalogram and heart rate were continuously monitored. We also studied the effect of sodium nitrite and hyperbaric oxygen administered before the poisoning (protective effect). In our experimental set, death of untreated poisoned animals occurred within 5 min. There is a parallel between modification of the EEG pattern and apnea. Respiratory arrest always preceded cardiac arrest. Pure oxygen (1 ATA O2) is effective in preventing death in experimental sulfide poisoning. 3 ATA oxygen was significantly more effective in preventing death than 1 ATA oxygen, or sodium nitrite alone. The best therapeutic regimen was a combination of 3 ATA oxygen and sodium nitrite administration.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalToxicology and Applied Pharmacology
Volume84
Issue number2
DOIs
StatePublished - Jun 30 1986
Externally publishedYes

Fingerprint

Sulfides
Poisoning
Rats
Sodium Nitrite
Atmosphere
Oxygen
Electroencephalography
Apnea
Heart Arrest
Intraperitoneal Injections
Animals
Heart Rate
Injections
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

The effect of hyperbaric oxygen on acute experimental sulfide poisoning in the rat. / Bitterman, N.; Talmi, Y.; Lerman, Amir; Melamed, Y.; Taitelman, U.

In: Toxicology and Applied Pharmacology, Vol. 84, No. 2, 30.06.1986, p. 325-328.

Research output: Contribution to journalArticle

Bitterman, N. ; Talmi, Y. ; Lerman, Amir ; Melamed, Y. ; Taitelman, U. / The effect of hyperbaric oxygen on acute experimental sulfide poisoning in the rat. In: Toxicology and Applied Pharmacology. 1986 ; Vol. 84, No. 2. pp. 325-328.
@article{afd250c938b14cc89a9d342f0a21cce7,
title = "The effect of hyperbaric oxygen on acute experimental sulfide poisoning in the rat",
abstract = "In order to evaluate the efficiency of hyperbaric oxygen in experimental acute sulfide poisoning, we studied the effect of 1 ATA (atmosphere absolute) oxygen and sodium nitrite therapy. We then studied the effect of oxygen at 3 ATA alone and in combination with intraperitoneal sodium nitrite injection on rats poisoned by intraperitoneal injection of LD75 sulfide. Electroencephalogram and heart rate were continuously monitored. We also studied the effect of sodium nitrite and hyperbaric oxygen administered before the poisoning (protective effect). In our experimental set, death of untreated poisoned animals occurred within 5 min. There is a parallel between modification of the EEG pattern and apnea. Respiratory arrest always preceded cardiac arrest. Pure oxygen (1 ATA O2) is effective in preventing death in experimental sulfide poisoning. 3 ATA oxygen was significantly more effective in preventing death than 1 ATA oxygen, or sodium nitrite alone. The best therapeutic regimen was a combination of 3 ATA oxygen and sodium nitrite administration.",
author = "N. Bitterman and Y. Talmi and Amir Lerman and Y. Melamed and U. Taitelman",
year = "1986",
month = "6",
day = "30",
doi = "10.1016/0041-008X(86)90140-7",
language = "English (US)",
volume = "84",
pages = "325--328",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - The effect of hyperbaric oxygen on acute experimental sulfide poisoning in the rat

AU - Bitterman, N.

AU - Talmi, Y.

AU - Lerman, Amir

AU - Melamed, Y.

AU - Taitelman, U.

PY - 1986/6/30

Y1 - 1986/6/30

N2 - In order to evaluate the efficiency of hyperbaric oxygen in experimental acute sulfide poisoning, we studied the effect of 1 ATA (atmosphere absolute) oxygen and sodium nitrite therapy. We then studied the effect of oxygen at 3 ATA alone and in combination with intraperitoneal sodium nitrite injection on rats poisoned by intraperitoneal injection of LD75 sulfide. Electroencephalogram and heart rate were continuously monitored. We also studied the effect of sodium nitrite and hyperbaric oxygen administered before the poisoning (protective effect). In our experimental set, death of untreated poisoned animals occurred within 5 min. There is a parallel between modification of the EEG pattern and apnea. Respiratory arrest always preceded cardiac arrest. Pure oxygen (1 ATA O2) is effective in preventing death in experimental sulfide poisoning. 3 ATA oxygen was significantly more effective in preventing death than 1 ATA oxygen, or sodium nitrite alone. The best therapeutic regimen was a combination of 3 ATA oxygen and sodium nitrite administration.

AB - In order to evaluate the efficiency of hyperbaric oxygen in experimental acute sulfide poisoning, we studied the effect of 1 ATA (atmosphere absolute) oxygen and sodium nitrite therapy. We then studied the effect of oxygen at 3 ATA alone and in combination with intraperitoneal sodium nitrite injection on rats poisoned by intraperitoneal injection of LD75 sulfide. Electroencephalogram and heart rate were continuously monitored. We also studied the effect of sodium nitrite and hyperbaric oxygen administered before the poisoning (protective effect). In our experimental set, death of untreated poisoned animals occurred within 5 min. There is a parallel between modification of the EEG pattern and apnea. Respiratory arrest always preceded cardiac arrest. Pure oxygen (1 ATA O2) is effective in preventing death in experimental sulfide poisoning. 3 ATA oxygen was significantly more effective in preventing death than 1 ATA oxygen, or sodium nitrite alone. The best therapeutic regimen was a combination of 3 ATA oxygen and sodium nitrite administration.

UR - http://www.scopus.com/inward/record.url?scp=0022597077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022597077&partnerID=8YFLogxK

U2 - 10.1016/0041-008X(86)90140-7

DO - 10.1016/0041-008X(86)90140-7

M3 - Article

C2 - 3715879

AN - SCOPUS:0022597077

VL - 84

SP - 325

EP - 328

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 2

ER -