The effect of hydroxyl radical scavenging on acute axial-random skin flap survival

Richard E. Hayden, Randal C. Paniello, Cecil S.T. Yeung, Steven L. Bello

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Dimethyl thiourea (DMTU), a known hydroxyl radical scavenger, was tested for its ability to improve survival in acute island skin flaps. Rats receiving 500 mg/kg DMTU 1 hour after flap elevation showed a 23.5% improved survival over saline controls. The role of the hydroxyl radical in ischemia/reperfusion injury, and its proposed mechanism, is discussed.

Original languageEnglish (US)
Pages (from-to)106-108
Number of pages3
JournalLaryngoscope
Volume98
Issue number1
DOIs
StatePublished - Jan 1988

ASJC Scopus subject areas

  • Otorhinolaryngology

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