The effect of glutathione and vitamins A, C, and E on acute skin flap survivals

Richard E Hayden, Randal C. Paniello, Cecil S T Yeung, Steven L. Bello, Steven M. Dawson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Vitamins A, C, and E act as antioxidants and as free radical scavengers in biological systems. Glutathione is involved in several reactions in vitamin metabolism and also plays an important role in cell membrane protection against lipid peroxidation by free radicals. We sought to use these natural defense mechanisms against oxygen free radicals formed during reperfusion of ischemic skin flaps. An acute axial random skin flap model was utilized in the rat. Vitamins or glutathione were administered by oral gastric tube or intravenously in the perioperative period, and survival of the flap was measured at 1 week. Glutathione, beta-carotene, ascorbic acid and alpha-D-tocopherol showed mean flap survival of 84% to 89%, each of which was significantly improved over saline controls (67% p<.0005). The mechanisms and biochemistry of these vitamins, and their interactions with other vitamins and with glutathione, are discussed, along with clinical implications of free radical scavenging and skin flap survival.

Original languageEnglish (US)
Pages (from-to)1176-1179
Number of pages4
JournalLaryngoscope
Volume97
Issue number10
StatePublished - 1987
Externally publishedYes

Fingerprint

Vitamin A
Vitamin E
Vitamins
Ascorbic Acid
Glutathione
Free Radicals
Skin
Free Radical Scavengers
Perioperative Period
Cytoprotection
beta Carotene
alpha-Tocopherol
Biochemistry
Lipid Peroxidation
Reperfusion
Reactive Oxygen Species
Stomach
Antioxidants
Cell Membrane

ASJC Scopus subject areas

  • Medicine(all)
  • Otorhinolaryngology

Cite this

Hayden, R. E., Paniello, R. C., Yeung, C. S. T., Bello, S. L., & Dawson, S. M. (1987). The effect of glutathione and vitamins A, C, and E on acute skin flap survivals. Laryngoscope, 97(10), 1176-1179.

The effect of glutathione and vitamins A, C, and E on acute skin flap survivals. / Hayden, Richard E; Paniello, Randal C.; Yeung, Cecil S T; Bello, Steven L.; Dawson, Steven M.

In: Laryngoscope, Vol. 97, No. 10, 1987, p. 1176-1179.

Research output: Contribution to journalArticle

Hayden, RE, Paniello, RC, Yeung, CST, Bello, SL & Dawson, SM 1987, 'The effect of glutathione and vitamins A, C, and E on acute skin flap survivals', Laryngoscope, vol. 97, no. 10, pp. 1176-1179.
Hayden RE, Paniello RC, Yeung CST, Bello SL, Dawson SM. The effect of glutathione and vitamins A, C, and E on acute skin flap survivals. Laryngoscope. 1987;97(10):1176-1179.
Hayden, Richard E ; Paniello, Randal C. ; Yeung, Cecil S T ; Bello, Steven L. ; Dawson, Steven M. / The effect of glutathione and vitamins A, C, and E on acute skin flap survivals. In: Laryngoscope. 1987 ; Vol. 97, No. 10. pp. 1176-1179.
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