TY - GEN
T1 - The effect of extracellular potassium concentration on muscle fiber conduction velocity examined using model simulation
AU - Fortune, E.
AU - Lowery, M. M.
PY - 2007
Y1 - 2007
N2 - During fatiguing contractions muscle fiber conduction velocity (CV) decreases progressively. The exact cause of this is not yet fully known, although recent studies suggest that changes in extracellular potassium concentration play an important role. A model was developed to examine the effect of accumulation of extracellular potassium ions on the muscle fiber action potential and its CV. As the extracellular potassium concentration was increased, the action potential progressively broadened, reduced in peak-peak amplitude and its CV decreased. However, when the inward rectifier channels were blocked, the changing shape of the action potential and the reduction of its CV with increasing extracellular potassium were dramatically reduced. The simulation results support the hypothesis that the reduction in muscle fiber CV observed during sustained fatiguing contractions may be due in part, to increased accumulation of extracellular potassium ions and suggest that the inward rectifier currents play an important role on the relationships observed.
AB - During fatiguing contractions muscle fiber conduction velocity (CV) decreases progressively. The exact cause of this is not yet fully known, although recent studies suggest that changes in extracellular potassium concentration play an important role. A model was developed to examine the effect of accumulation of extracellular potassium ions on the muscle fiber action potential and its CV. As the extracellular potassium concentration was increased, the action potential progressively broadened, reduced in peak-peak amplitude and its CV decreased. However, when the inward rectifier channels were blocked, the changing shape of the action potential and the reduction of its CV with increasing extracellular potassium were dramatically reduced. The simulation results support the hypothesis that the reduction in muscle fiber CV observed during sustained fatiguing contractions may be due in part, to increased accumulation of extracellular potassium ions and suggest that the inward rectifier currents play an important role on the relationships observed.
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U2 - 10.1109/IEMBS.2007.4352892
DO - 10.1109/IEMBS.2007.4352892
M3 - Conference contribution
C2 - 18002558
AN - SCOPUS:57649220703
SN - 1424407885
SN - 9781424407880
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 2726
EP - 2729
BT - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
T2 - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Y2 - 23 August 2007 through 26 August 2007
ER -