The effect of dietary intervention on irritable bowel syndrome: A systematic review

Paul Moayyedi, Eamonn M M Quigley, Brian E. Lacy, Anthony J. Lembo, Yuri Ann Saito Loftus, Lawrence R. Schiller, Edy E. Soffer, Brennan M R Spiegel, Alexander C. Ford

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

OBJECTIVES: Elimination diets have been used for many years to treat irritable bowel syndrome (IBS). These approaches had fallen out of favor until a recent resurgence, which was based on new randomized controlled trial (RCT) data that suggested it might be effective. The evidence for the efficacy of dietary therapies has not been evaluated systematically. We have therefore conducted a systematic review to examine this issue. METHODS: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched up to December 2013. Trials recruiting adults with IBS, which compared any form of dietary restriction or addition of an offending food group in patients already on a restricted diet vs. placebo, control therapy, or "usual management", were eligible. Dichotomous symptom data were pooled to obtain a relative risk of remaining symptomatic after therapy as well as the number needed to treat with a 95% confidence interval. RESULTS: We identified 17 RCTs involving 1,568 IBS patients that assessed elimination diets. Only three RCTs involving 230 patients met our eligibility criteria, all of which evaluated different approaches, and thus a meta-analysis could not be conducted. CONCLUSIONS: More evidence is needed before generally recommending elimination diets for IBS patients.

Original languageEnglish (US)
Article numbere107
JournalClinical and Translational Gastroenterology
Volume6
Issue number8
DOIs
StatePublished - Aug 20 2015

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Irritable Bowel Syndrome
Diet
Numbers Needed To Treat
MEDLINE
Meta-Analysis
Therapeutics
Randomized Controlled Trials
Placebos
Confidence Intervals
Food

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The effect of dietary intervention on irritable bowel syndrome : A systematic review. / Moayyedi, Paul; Quigley, Eamonn M M; Lacy, Brian E.; Lembo, Anthony J.; Saito Loftus, Yuri Ann; Schiller, Lawrence R.; Soffer, Edy E.; Spiegel, Brennan M R; Ford, Alexander C.

In: Clinical and Translational Gastroenterology, Vol. 6, No. 8, e107, 20.08.2015.

Research output: Contribution to journalArticle

Moayyedi, P, Quigley, EMM, Lacy, BE, Lembo, AJ, Saito Loftus, YA, Schiller, LR, Soffer, EE, Spiegel, BMR & Ford, AC 2015, 'The effect of dietary intervention on irritable bowel syndrome: A systematic review', Clinical and Translational Gastroenterology, vol. 6, no. 8, e107. https://doi.org/10.1038/ctg.2015.21
Moayyedi, Paul ; Quigley, Eamonn M M ; Lacy, Brian E. ; Lembo, Anthony J. ; Saito Loftus, Yuri Ann ; Schiller, Lawrence R. ; Soffer, Edy E. ; Spiegel, Brennan M R ; Ford, Alexander C. / The effect of dietary intervention on irritable bowel syndrome : A systematic review. In: Clinical and Translational Gastroenterology. 2015 ; Vol. 6, No. 8.
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