DIE WIRKUNG VON ZYTOKINEN AUF DAS REGENERATIONSERGEBNIS KOMPRIMIERTER NERVENWURZELN UND DURCHTRENNTER PERIPHERER NERVEN

Translated title of the contribution: The effect of cytokines on regeneration of compressed nerve roots and transsected peripheral nerves

P. Wehling, J. Wirths, C. H. Evans

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The possible beneficial effect of Interleukin-1 (IL-1) on nerve regeneration was studied using clinical, neurophysiological and histomorphological methods. The sciatic nerves of Wistar rats were transsected and the severed ends abutted, sewn together and covered with fibrin adhesive. In a second group the lumbar-sacral nerve roots were exposed, IL-1 was injected and compression of the nerve roots was carried out. The region surrounding the lesion was infused with either saline (controls) or IL-1 (treatment group) in both groups. Compared to the controls, the treated animals showed a significant improvement of nerve regeneration as measured by clinical and neurophysiological parameters. After 3 months of observation, the total number of myelinated axons distal to the site of lesion was increased, while the fiber diameter distribution was unchanged. It is likely that cloned IL-1 will soon become available for human treatment. The present results indicate that it may be worthwile to investigate its usefulness in the treatment of peripheral nerve injury in primates and humans.

Original languageGerman
Pages (from-to)83-93
Number of pages11
JournalZeitschrift fur Orthopadie und Ihre Grenzgebiete
Volume131
Issue number1
StatePublished - Jan 1 1993

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ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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