The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis

Stephen A. Klassen; Jonathon W. Senefeld; Patrick W. Johnson; Rickey E. Carter; Chad C. Wiggins; Shmuel Shoham; Brenda J. Grossman; Jeffrey P. Henderson; James Musser; Eric Salazar; William R. Hartman; Nicole M. Bouvier; Sean T.H. Liu; Liise anne Pirofski; Sarah E. Baker; Noud van Helmond; R. Scott Wright; De Lisa Fairweather; Katelyn A. Bruno; Zhen Wang; Nigel S. Paneth; Arturo Casadevall; Michael J. Joyner

doi:10.1016/j.mayocp.2021.02.008

The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis

Stephen A. Klassen, Jonathon W. Senefeld, Patrick W. Johnson, Rickey E. Carter, Chad C. Wiggins, Shmuel Shoham, Brenda J. Grossman, Jeffrey P. Henderson, James Musser, Eric Salazar, William R. Hartman, Nicole M. Bouvier, Sean T.H. Liu, Liise anne Pirofski, Sarah E. Baker, Noud van Helmond, R. Scott Wright, De Lisa Fairweather, Katelyn A. Bruno, Zhen WangNigel S. Paneth, Arturo Casadevall, Michael J. Joyner

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.

Original language	English (US)
Pages (from-to)	1262-1275
Number of pages	14
Journal	Mayo Clinic proceedings
Volume	96
Issue number	5
DOIs	https://doi.org/10.1016/j.mayocp.2021.02.008
State	Published - May 2021

ASJC Scopus subject areas

General Medicine

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10.1016/j.mayocp.2021.02.008

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Klassen, S. A., Senefeld, J. W., Johnson, P. W., Carter, R. E., Wiggins, C. C., Shoham, S., Grossman, B. J., Henderson, J. P., Musser, J., Salazar, E., Hartman, W. R., Bouvier, N. M., Liu, S. T. H., Pirofski, L. A., Baker, S. E., van Helmond, N., Wright, R. S., Fairweather, D. L., Bruno, K. A., ... Joyner, M. J. (2021). The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis. Mayo Clinic proceedings, 96(5), 1262-1275. https://doi.org/10.1016/j.mayocp.2021.02.008

Klassen, SA, Senefeld, JW, Johnson, PW, Carter, RE, Wiggins, CC, Shoham, S, Grossman, BJ, Henderson, JP, Musser, J, Salazar, E, Hartman, WR, Bouvier, NM, Liu, STH, Pirofski, LA, Baker, SE, van Helmond, N, Wright, RS , Fairweather, DL , Bruno, KA , Wang, Z, Paneth, NS, Casadevall, A & Joyner, MJ 2021, 'The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis', Mayo Clinic proceedings, vol. 96, no. 5, pp. 1262-1275. https://doi.org/10.1016/j.mayocp.2021.02.008

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title = "The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis",

abstract = "To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.",

author = "Klassen, {Stephen A.} and Senefeld, {Jonathon W.} and Johnson, {Patrick W.} and Carter, {Rickey E.} and Wiggins, {Chad C.} and Shmuel Shoham and Grossman, {Brenda J.} and Henderson, {Jeffrey P.} and James Musser and Eric Salazar and Hartman, {William R.} and Bouvier, {Nicole M.} and Liu, {Sean T.H.} and Pirofski, {Liise anne} and Baker, {Sarah E.} and {van Helmond}, Noud and Wright, {R. Scott} and Fairweather, {De Lisa} and Bruno, {Katelyn A.} and Zhen Wang and Paneth, {Nigel S.} and Arturo Casadevall and Joyner, {Michael J.}",

note = "Publisher Copyright: {\textcopyright} 2021 Mayo Foundation for Medical Education and Research",

year = "2021",

month = may,

doi = "10.1016/j.mayocp.2021.02.008",

language = "English (US)",

volume = "96",

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journal = "Mayo Clinic proceedings",

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AU - Klassen, Stephen A.

AU - Senefeld, Jonathon W.

AU - Johnson, Patrick W.

AU - Carter, Rickey E.

AU - Wiggins, Chad C.

AU - Shoham, Shmuel

AU - Grossman, Brenda J.

AU - Henderson, Jeffrey P.

AU - Musser, James

AU - Salazar, Eric

AU - Hartman, William R.

AU - Bouvier, Nicole M.

AU - Liu, Sean T.H.

AU - Pirofski, Liise anne

AU - Baker, Sarah E.

AU - van Helmond, Noud

AU - Wright, R. Scott

AU - Fairweather, De Lisa

AU - Bruno, Katelyn A.

AU - Wang, Zhen

AU - Paneth, Nigel S.

AU - Casadevall, Arturo

AU - Joyner, Michael J.

PY - 2021/5

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N2 - To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.

AB - To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.

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The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis

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