The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk

W. Cozen, James R Cerhan, O. Martinez-Maza, M. H. Ward, M. Linet, J. S. Colt, S. Davis, R. K. Severson, P. Hartge, L. Bernstein

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: Since adult immune responsiveness is influenced by early childhood exposures, we examined the role of family size, history of atopic disease, and other childhood immune-related exposures in a multi-center case-control study of NHL. Methods: Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Medicare files database. Multivariable logistic regression was used to estimate risk. Results: A history of any allergy (excluding drug allergies), decreased risk of all NHL (Odds Ratio [OR] = 0.7, 95% Confidence Interval [CI] = 0.6-1.0), diffuse large B-cell lymphoma [DLBCL] (OR = 0.6, 95% CI = 0.4-0.9), and follicular NHL (OR = 0.7, 95 CI = 0.5, 1.0). A similar effect was observed for hay fever. A history of eczema was associated with an increased risk of follicular lymphoma (OR = 1.9, 95% CI = 1.1-3.4), but not DLBCL (OR = 1.1, 95% CI = 0.6-2.0). Asthma did not affect risk. Youngest compared to oldest siblings had a 90% increased risk of DLBCL (95% CI = 1.2-3.1; p for trend with increasing birth order = 0.006), but not follicular lymphoma (OR = 1.1, 95% CI = 0.6-1.8). Conclusions: We infer that some childhood and immune-related factors may alter NHL risk.

Original languageEnglish (US)
Pages (from-to)821-831
Number of pages11
JournalCancer Causes and Control
Volume18
Issue number8
DOIs
StatePublished - Oct 2007

Fingerprint

Crowding
Immunologic Factors
Non-Hodgkin's Lymphoma
Confidence Intervals
Odds Ratio
Lymphoma, Large B-Cell, Diffuse
Follicular Lymphoma
Drug Hypersensitivity
Birth Order
Seasonal Allergic Rhinitis
Los Angeles
Eczema
Medicare
Registries
Case-Control Studies
Siblings
Hypersensitivity
Asthma
Logistic Models
Databases

Keywords

  • Allergy
  • Atopy
  • Birth order
  • Childhood Exposures
  • Immune response
  • Non-Hodgkin lymphoma
  • Sibship size

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk. / Cozen, W.; Cerhan, James R; Martinez-Maza, O.; Ward, M. H.; Linet, M.; Colt, J. S.; Davis, S.; Severson, R. K.; Hartge, P.; Bernstein, L.

In: Cancer Causes and Control, Vol. 18, No. 8, 10.2007, p. 821-831.

Research output: Contribution to journalArticle

Cozen, W, Cerhan, JR, Martinez-Maza, O, Ward, MH, Linet, M, Colt, JS, Davis, S, Severson, RK, Hartge, P & Bernstein, L 2007, 'The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk', Cancer Causes and Control, vol. 18, no. 8, pp. 821-831. https://doi.org/10.1007/s10552-007-9025-5
Cozen, W. ; Cerhan, James R ; Martinez-Maza, O. ; Ward, M. H. ; Linet, M. ; Colt, J. S. ; Davis, S. ; Severson, R. K. ; Hartge, P. ; Bernstein, L. / The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk. In: Cancer Causes and Control. 2007 ; Vol. 18, No. 8. pp. 821-831.
@article{fc85a0ecd197423f8b5de203ae939d79,
title = "The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk",
abstract = "Objective: Since adult immune responsiveness is influenced by early childhood exposures, we examined the role of family size, history of atopic disease, and other childhood immune-related exposures in a multi-center case-control study of NHL. Methods: Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Medicare files database. Multivariable logistic regression was used to estimate risk. Results: A history of any allergy (excluding drug allergies), decreased risk of all NHL (Odds Ratio [OR] = 0.7, 95{\%} Confidence Interval [CI] = 0.6-1.0), diffuse large B-cell lymphoma [DLBCL] (OR = 0.6, 95{\%} CI = 0.4-0.9), and follicular NHL (OR = 0.7, 95 CI = 0.5, 1.0). A similar effect was observed for hay fever. A history of eczema was associated with an increased risk of follicular lymphoma (OR = 1.9, 95{\%} CI = 1.1-3.4), but not DLBCL (OR = 1.1, 95{\%} CI = 0.6-2.0). Asthma did not affect risk. Youngest compared to oldest siblings had a 90{\%} increased risk of DLBCL (95{\%} CI = 1.2-3.1; p for trend with increasing birth order = 0.006), but not follicular lymphoma (OR = 1.1, 95{\%} CI = 0.6-1.8). Conclusions: We infer that some childhood and immune-related factors may alter NHL risk.",
keywords = "Allergy, Atopy, Birth order, Childhood Exposures, Immune response, Non-Hodgkin lymphoma, Sibship size",
author = "W. Cozen and Cerhan, {James R} and O. Martinez-Maza and Ward, {M. H.} and M. Linet and Colt, {J. S.} and S. Davis and Severson, {R. K.} and P. Hartge and L. Bernstein",
year = "2007",
month = "10",
doi = "10.1007/s10552-007-9025-5",
language = "English (US)",
volume = "18",
pages = "821--831",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "8",

}

TY - JOUR

T1 - The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk

AU - Cozen, W.

AU - Cerhan, James R

AU - Martinez-Maza, O.

AU - Ward, M. H.

AU - Linet, M.

AU - Colt, J. S.

AU - Davis, S.

AU - Severson, R. K.

AU - Hartge, P.

AU - Bernstein, L.

PY - 2007/10

Y1 - 2007/10

N2 - Objective: Since adult immune responsiveness is influenced by early childhood exposures, we examined the role of family size, history of atopic disease, and other childhood immune-related exposures in a multi-center case-control study of NHL. Methods: Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Medicare files database. Multivariable logistic regression was used to estimate risk. Results: A history of any allergy (excluding drug allergies), decreased risk of all NHL (Odds Ratio [OR] = 0.7, 95% Confidence Interval [CI] = 0.6-1.0), diffuse large B-cell lymphoma [DLBCL] (OR = 0.6, 95% CI = 0.4-0.9), and follicular NHL (OR = 0.7, 95 CI = 0.5, 1.0). A similar effect was observed for hay fever. A history of eczema was associated with an increased risk of follicular lymphoma (OR = 1.9, 95% CI = 1.1-3.4), but not DLBCL (OR = 1.1, 95% CI = 0.6-2.0). Asthma did not affect risk. Youngest compared to oldest siblings had a 90% increased risk of DLBCL (95% CI = 1.2-3.1; p for trend with increasing birth order = 0.006), but not follicular lymphoma (OR = 1.1, 95% CI = 0.6-1.8). Conclusions: We infer that some childhood and immune-related factors may alter NHL risk.

AB - Objective: Since adult immune responsiveness is influenced by early childhood exposures, we examined the role of family size, history of atopic disease, and other childhood immune-related exposures in a multi-center case-control study of NHL. Methods: Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Medicare files database. Multivariable logistic regression was used to estimate risk. Results: A history of any allergy (excluding drug allergies), decreased risk of all NHL (Odds Ratio [OR] = 0.7, 95% Confidence Interval [CI] = 0.6-1.0), diffuse large B-cell lymphoma [DLBCL] (OR = 0.6, 95% CI = 0.4-0.9), and follicular NHL (OR = 0.7, 95 CI = 0.5, 1.0). A similar effect was observed for hay fever. A history of eczema was associated with an increased risk of follicular lymphoma (OR = 1.9, 95% CI = 1.1-3.4), but not DLBCL (OR = 1.1, 95% CI = 0.6-2.0). Asthma did not affect risk. Youngest compared to oldest siblings had a 90% increased risk of DLBCL (95% CI = 1.2-3.1; p for trend with increasing birth order = 0.006), but not follicular lymphoma (OR = 1.1, 95% CI = 0.6-1.8). Conclusions: We infer that some childhood and immune-related factors may alter NHL risk.

KW - Allergy

KW - Atopy

KW - Birth order

KW - Childhood Exposures

KW - Immune response

KW - Non-Hodgkin lymphoma

KW - Sibship size

UR - http://www.scopus.com/inward/record.url?scp=34547192143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547192143&partnerID=8YFLogxK

U2 - 10.1007/s10552-007-9025-5

DO - 10.1007/s10552-007-9025-5

M3 - Article

C2 - 17588155

AN - SCOPUS:34547192143

VL - 18

SP - 821

EP - 831

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 8

ER -