Abstract
Aim: To evaluate the effectiveness of antihypertensives in reducing neurocognitive outcomes in elderly patients. Patients & methods: We conducted a systematic literature search of randomized trials in which hypertensive patients with a mean age ≥65 years received antihypertensive or control treatment. Outcomes were stroke, transient ischemic attack, cognitive decline and dementia. We included 14 trials for meta-analysis. Results: Compared to placebo, antihypertensive treatment reduced the risk of stroke (RR: 0.67 [95% CI: 0.57-0.79]). Reduced risk was significant for transient ischemic attack, fatal stroke, nonfatal stroke and total stroke. There were insufficient data to compare individual agents. Conclusion: Antihypertensive treatment is associated with a significant reduction in stroke in elderly individuals. Reductions in dementia and cognitive decline were not significant; however, there was short follow-up. Comparative effectiveness evidence is limited.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 237-248 |
| Number of pages | 12 |
| Journal | Future Cardiology |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2016 |
Keywords
- aged
- cognition
- dementia
- hypertension
- stroke
ASJC Scopus subject areas
- Molecular Medicine
- Cardiology and Cardiovascular Medicine