The effect of antihypertensive treatment on the incidence of stroke and cognitive decline in the elderly: A meta-analysis

Christine Parsons, Mohammad H Murad, Stuart Andersen, Farouk Mookadam, Helene Labonte

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Aim: To evaluate the effectiveness of antihypertensives in reducing neurocognitive outcomes in elderly patients. Patients & methods: We conducted a systematic literature search of randomized trials in which hypertensive patients with a mean age ≥65 years received antihypertensive or control treatment. Outcomes were stroke, transient ischemic attack, cognitive decline and dementia. We included 14 trials for meta-analysis. Results: Compared to placebo, antihypertensive treatment reduced the risk of stroke (RR: 0.67 [95% CI: 0.57-0.79]). Reduced risk was significant for transient ischemic attack, fatal stroke, nonfatal stroke and total stroke. There were insufficient data to compare individual agents. Conclusion: Antihypertensive treatment is associated with a significant reduction in stroke in elderly individuals. Reductions in dementia and cognitive decline were not significant; however, there was short follow-up. Comparative effectiveness evidence is limited.

Original languageEnglish (US)
Pages (from-to)237-248
Number of pages12
JournalFuture Cardiology
Volume12
Issue number2
DOIs
StatePublished - Mar 1 2016

Keywords

  • aged
  • cognition
  • dementia
  • hypertension
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Molecular Medicine

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