The effect of age on protein metabolism

Kevin R. Short, K Sreekumaran Nair

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The mechanisms of senescence remain to be fully defined. This review focuses on recent advances in our understanding of body protein turnover, which is essential for the remodeling of tissues and production of specific proteins in time of need. Recent advances in technology make it possible to measure the synthesis rate of muscle myosin heavy chain, mitochondrial proteins and sarcoplasmic proteins, providing insight into the mechanisms of the sarcopenia of aging. A reduced synthesis rate of myosin heavy chain and mitochondrial protein may explain muscle weakness and fatiguability that occurs with aging. Aging also seems to affect selected liver proteins such as fibrinogen. The potential roles of exercise and hormone replacement in slowing the age-related decline in protein turnover is discussed. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume3
Issue number1
DOIs
StatePublished - Jan 2000

Fingerprint

protein metabolism
myosin heavy chains
Myosin Heavy Chains
Mitochondrial Proteins
Proteins
proteins
sarcopenia
liver protein
muscles
synthesis
body protein
Sarcopenia
fibrinogen
Muscle Weakness
exercise
Fibrinogen
hormones
Hormones
Technology
Muscles

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

The effect of age on protein metabolism. / Short, Kevin R.; Nair, K Sreekumaran.

In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 3, No. 1, 01.2000, p. 39-44.

Research output: Contribution to journalArticle

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