TY - JOUR
T1 - The early repolarization pattern in the general population
T2 - Clinical correlates and heritability
AU - Noseworthy, Peter A.
AU - Tikkanen, Jani T.
AU - Porthan, Kimmo
AU - Oikarinen, Lasse
AU - Pietil, Arto
AU - Harald, Kennet
AU - Peloso, Gina M.
AU - Merchant, Faisal M.
AU - Jula, Antti
AU - Vnnen, Heikki
AU - Hwang, Shih Jen
AU - O'Donnell, Christopher J.
AU - Salomaa, Veikko
AU - Newton-Cheh, Christopher
AU - Huikuri, Heikki V.
PY - 2011/5/31
Y1 - 2011/5/31
N2 - Objectives: This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts. Background: There is growing recognition that ERP is associated with adverse outcomes. Methods: Participants of the Framingham Heart Study (FHS) (N = 3,995) and the Health 2000 Survey (H2K) (N = 5,489) were included. ERP was defined as a J-point elevation <0.1 mV in <2 leads in either the inferior (II, III, aVF) or lateral (I, aVL, V46) territory or both. We tested the association between clinical characteristics and ERP, and estimated sibling recurrence risk. Results: ERP was present in 243 of 3,955 (6.1%) of FHS and 180 of 5,489 (3.3%) of H2K subjects. Male sex, younger age, lower systolic blood pressure, higher Sokolow-Lyon index, and lower Cornell voltage were independently associated with the presence of ERP. In the FHS sample, siblings of individuals with ERP had an ERP prevalence of 11.6% (recurrence risk ratio of 1.89). Siblings of individuals with ERP had an increased unadjusted odds of ERP (odds ratio: 2.22, 95% confidence interval: 1.01 to 4.85, p = 0.047). Conclusions: ERP has strong association with clinical factors and has evidence for a heritable basis in the general population. Further assessment of the genetic determinants of ERP is warranted.
AB - Objectives: This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts. Background: There is growing recognition that ERP is associated with adverse outcomes. Methods: Participants of the Framingham Heart Study (FHS) (N = 3,995) and the Health 2000 Survey (H2K) (N = 5,489) were included. ERP was defined as a J-point elevation <0.1 mV in <2 leads in either the inferior (II, III, aVF) or lateral (I, aVL, V46) territory or both. We tested the association between clinical characteristics and ERP, and estimated sibling recurrence risk. Results: ERP was present in 243 of 3,955 (6.1%) of FHS and 180 of 5,489 (3.3%) of H2K subjects. Male sex, younger age, lower systolic blood pressure, higher Sokolow-Lyon index, and lower Cornell voltage were independently associated with the presence of ERP. In the FHS sample, siblings of individuals with ERP had an ERP prevalence of 11.6% (recurrence risk ratio of 1.89). Siblings of individuals with ERP had an increased unadjusted odds of ERP (odds ratio: 2.22, 95% confidence interval: 1.01 to 4.85, p = 0.047). Conclusions: ERP has strong association with clinical factors and has evidence for a heritable basis in the general population. Further assessment of the genetic determinants of ERP is warranted.
KW - ECG
KW - early repolarization
KW - heritability
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U2 - 10.1016/j.jacc.2011.04.003
DO - 10.1016/j.jacc.2011.04.003
M3 - Article
C2 - 21600720
AN - SCOPUS:79957569046
SN - 0735-1097
VL - 57
SP - 2284
EP - 2289
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 22
ER -