The dynamic organization of gene-regulatory machinery in nuclear microenvironments

Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Jitesh Pratap, Amjad Javed, Martin Montecino, Janet L. Stein, Andre J. van Wijnen, Jane B. Lian, Gary S. Stein

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations

Abstract

Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene expression with the combinatorial assembly of the regulatory machinery for biological control. In addition, a mitotic cycle of selective partitioning and sequential restoration of the transcriptional machinery provides a basis for the reassembly of regulatory complexes to render progeny cells competent for phenotypic gene expression. When this intranuclear targeting and localization of regulatory proteins is compromised, diseases, such as cancer, can occur. A detailed understanding of this process will provide further options for diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)128-133
Number of pages6
JournalEMBO Reports
Volume6
Issue number2
DOIs
StatePublished - 2005

Keywords

  • Chromatin organization
  • Gene regulation
  • Intranuclear transport
  • Nuclear microenvironments
  • Transcriptional control

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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