TY - JOUR
T1 - The dynamic biliary epithelia
T2 - Molecules, pathways, and disease
AU - O'Hara, Steven P.
AU - Tabibian, James H.
AU - Splinter, Patrick L.
AU - Larusso, Nicholas F.
N1 - Funding Information:
The underlying research reported in the study was funded by the NIH Institutes of Health.
Funding Information:
This work was supported by NIH grants R01 DK057993 and DK024031 (to NF LaRusso), R01 AI089713 (to SP O’Hara), and P30DK084567 ( Mayo Clinic Center for Cell Signaling in Gastroenterology ).
PY - 2013/3
Y1 - 2013/3
N2 - Cholangiocytes, the cells lining bile ducts, are a heterogenous, highly dynamic population of epithelial cells. While these cells comprise a small fraction of the total cellular component of the liver, they perform the essential role of bile modification and transport of biliary and blood constituents. From a pathophysiological standpoint, cholangiocytes are the target of a diverse group of biliary disorders, collectively referred to as the cholangiopathies. To date, the cause of most cholangiopathies remains obscure. It is known, however, that cholangiocytes exist in an environment rich in potential mediators of cellular injury, express receptors that recognize potential injurious insults, and participate in portal tract repair processes following hepatic injury. As such, cholangiocytes may not be only a passive target, but are likely directly and actively involved in the pathogenesis of cholangiopathies. Here, we briefly summarize the characteristics of the reactive cholangiocyte and cholangiocyte responses to potentially injurious endogenous and exogenous molecules, and in addition, present emerging concepts in our understanding of the etiopathogenesis of several cholangiopathies.
AB - Cholangiocytes, the cells lining bile ducts, are a heterogenous, highly dynamic population of epithelial cells. While these cells comprise a small fraction of the total cellular component of the liver, they perform the essential role of bile modification and transport of biliary and blood constituents. From a pathophysiological standpoint, cholangiocytes are the target of a diverse group of biliary disorders, collectively referred to as the cholangiopathies. To date, the cause of most cholangiopathies remains obscure. It is known, however, that cholangiocytes exist in an environment rich in potential mediators of cellular injury, express receptors that recognize potential injurious insults, and participate in portal tract repair processes following hepatic injury. As such, cholangiocytes may not be only a passive target, but are likely directly and actively involved in the pathogenesis of cholangiopathies. Here, we briefly summarize the characteristics of the reactive cholangiocyte and cholangiocyte responses to potentially injurious endogenous and exogenous molecules, and in addition, present emerging concepts in our understanding of the etiopathogenesis of several cholangiopathies.
KW - Biliary
KW - Cholangiocytes
KW - Cholangiopathy
KW - Reactivity
KW - Repair
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U2 - 10.1016/j.jhep.2012.10.011
DO - 10.1016/j.jhep.2012.10.011
M3 - Review article
C2 - 23085249
AN - SCOPUS:84874105072
SN - 0168-8278
VL - 58
SP - 575
EP - 582
JO - Journal of hepatology
JF - Journal of hepatology
IS - 3
ER -