TY - JOUR
T1 - The double life of NK receptors
T2 - Stimulation or co-stimulation?
AU - Snyder, Melissa R.
AU - Weyand, Cornelia M.
AU - Goronzy, Jörg J.
N1 - Funding Information:
This work was supported by NIH grants (R01 AI44142, R01 AR42527, R01 AG15043 and R01 AR41974) and by the Mayo Foundation. We thank James W. Fulbright for help with figure preparation and editorial assistance, and Linda H. Arneson for secretarial support.
PY - 2004/1
Y1 - 2004/1
N2 - Stimulatory killer immunoglobulin-like receptors, NKG2D and stimulatory receptors of the CD94-NKG2 family have duplicity in function. On natural killer (NK) cells, these receptors act as independent and competent recognition units. Stimulatory NK receptors also appear on subsets of effector T cells, particularly those that have replicated extensively. When expressed on T cells, they amplify signals mediated through the T-cell antigen receptor and, thus, function as co-stimulatory, but not direct stimulatory, molecules. One mechanism responsible for this dichotomy is the differential expression of adaptor molecules. This duplicity in function, which is not seen for other co-stimulatory molecules, is responsible for the unique context information provided by the NK receptors, and it could explain their involvement in chronic inflammation and autoimmunity.
AB - Stimulatory killer immunoglobulin-like receptors, NKG2D and stimulatory receptors of the CD94-NKG2 family have duplicity in function. On natural killer (NK) cells, these receptors act as independent and competent recognition units. Stimulatory NK receptors also appear on subsets of effector T cells, particularly those that have replicated extensively. When expressed on T cells, they amplify signals mediated through the T-cell antigen receptor and, thus, function as co-stimulatory, but not direct stimulatory, molecules. One mechanism responsible for this dichotomy is the differential expression of adaptor molecules. This duplicity in function, which is not seen for other co-stimulatory molecules, is responsible for the unique context information provided by the NK receptors, and it could explain their involvement in chronic inflammation and autoimmunity.
UR - http://www.scopus.com/inward/record.url?scp=0345772230&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345772230&partnerID=8YFLogxK
U2 - 10.1016/j.it.2003.10.011
DO - 10.1016/j.it.2003.10.011
M3 - Review article
C2 - 14698281
AN - SCOPUS:0345772230
SN - 1471-4906
VL - 25
SP - 25
EP - 32
JO - Trends in Immunology
JF - Trends in Immunology
IS - 1
ER -