The Dohner fluorescence in situ hybridization prognostic classification of chronic lymphocytic leukaemia (CLL): The CLL Research Consortium experience

Daniel L. Van Dyke, Lillian Werner, Laura Z. Rassenti, Donna Neuberg, Emanuella Ghia, Nyla A. Heerema, Paola Dal Cin, Marie Dell Aquila, Chandrika Sreekantaiah, Andrew W. Greaves, Thomas J. Kipps, Neil E. Kay

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

This study revisited the Dohner prognostic hierarchy in a cohort of 1585 well-documented patients with chronic lymphocytic leukaemia. The duration of both time to first treatment (TTFT) and overall survival (OS) were significantly longer than observed previously, and this is at least partly due to improved therapeutic options. Deletion 13q remains the most favourable prognostic group with median TTFT and OS from fluorescence in situ hybridization (FISH) testing of 72 months and >12 years, respectively. Deletion 11q had the poorest median TTFT (22 months) and 17p deletion the poorest median OS (5 years). The percentages of abnormal nuclei were significantly associated with differential TTFT for the trisomy 12, 13q and 17p deletion cohorts but not for the 11q deletion cohort. From the date of the first FISH study, patients with >85% 13q deletion nuclei had a notably shorter TTFT (24 months). Patients with ≤20% 17p deletion nuclei had longer median TTFT and OS from the date of the first FISH study (44 months and 11 years), and were more likely to be IGHV mutated.

Original languageEnglish (US)
Pages (from-to)105-113
Number of pages9
JournalBritish journal of haematology
Volume173
Issue number1
DOIs
StatePublished - Apr 1 2016

Keywords

  • Chronic lymphocytic leukaemia
  • Cytogenetics
  • Fluorescence in situ hybridization
  • Leukaemia

ASJC Scopus subject areas

  • Hematology

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