The distribution of myelin-associated glycoprotein and myelin basic protein in actively demyelinating multiple sclerosis lesions

J. W. Prineas, E. E. Kwon, Nancy H. Sternberger, Vanda A. Lennon

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Active plaques from 4 patients with multiple sclerosis were examined for myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) using the peroxidase-antiperoxidase (PAP) immunocytochemical procedure applied to paraffin sections. MBP loss was intimately related to the presence of infiltrating macrophages which appeared to remove MBP-positive fragments directly off intact myelin sheaths. Phagocytosis of MAG-positive myelin sheaths was also observed. These findings support previous morphological studies that suggest that phagocytosis by macrophages of myelin attached to axons is an important mechanism of demyelination in multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)251-264
Number of pages14
JournalJournal of neuroimmunology
Volume6
Issue number4
DOIs
StatePublished - Jul 1984

Keywords

  • (MAG)
  • (MBP)
  • Demyelination
  • Macrophages
  • Multiple sclerosis
  • Myelin basic protein
  • Myelin sheaths
  • Myelin-associated glycoprotein
  • Peroxidase
  • antiperoxidase (PAP) immunocytochemical procedure

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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