Abstract
Active plaques from 4 patients with multiple sclerosis were examined for myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) using the peroxidase-antiperoxidase (PAP) immunocytochemical procedure applied to paraffin sections. MBP loss was intimately related to the presence of infiltrating macrophages which appeared to remove MBP-positive fragments directly off intact myelin sheaths. Phagocytosis of MAG-positive myelin sheaths was also observed. These findings support previous morphological studies that suggest that phagocytosis by macrophages of myelin attached to axons is an important mechanism of demyelination in multiple sclerosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 251-264 |
| Number of pages | 14 |
| Journal | Journal of neuroimmunology |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1984 |
Keywords
- (MAG)
- (MBP)
- Demyelination
- Macrophages
- Multiple sclerosis
- Myelin basic protein
- Myelin sheaths
- Myelin-associated glycoprotein
- Peroxidase
- antiperoxidase (PAP) immunocytochemical procedure
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology
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Cite this
Prineas, J. W., Kwon, E. E., Sternberger, N. H., & Lennon, V. A. (1984). The distribution of myelin-associated glycoprotein and myelin basic protein in actively demyelinating multiple sclerosis lesions. Journal of neuroimmunology, 6(4), 251-264. https://doi.org/10.1016/0165-5728(84)90012-2