@article{bfe82cf04e294f3ca1eb187e3fcadd94,
title = "The distinct gene expression profiles of chronic lymphocytic leukemia and multiple myeloma suggest different anti-apoptotic mechanisms but predict only some differences in phenotype",
abstract = "We compared gene expression in purified tumor cells from untreated patients with chronic lymphocytic (CLL) (n=24) and newly diagnosed multiple myeloma (MM) (n=29) using the Affymetrix HuGeneFL microarray with probes for approximately 6800 genes. Hierarchical clustering analysis showed that CLL and MM have distinct expression profiles (class prediction). Gene and protein expression (measured by flow cytometry) correlated well for CD19, CD20, CD23, and CD138 in CLL and MM, but not for immunoglobulin light chain, CD38 and CD79b in CLL, or CD45 and CD52 in MM. CLL and MM differentially expressed 18% of 130 apoptosis related genes, suggesting differences in mechanisms of cell survival.",
keywords = "Chronic lymphocytic leukemia, Gene expression, Multiple myeloma",
author = "Zent, {Clive S.} and Fenghuang Zhan and Schichman, {Steven A.} and Bumm, {Klaus H.W.} and Pei Lin and Chen, {James B.} and Shaughnessy, {John D.}",
note = "Funding Information: This work was funded in part by: American Cancer Society Institutional Research Grant #IRG-021-06 (Clive S. Zent and Steven A. Schichman); the University of Arkansas for Medical Sciences College of Medicine (Clive S. Zent); the Biomedical Research Foundation (Clive S. Zent and Steven A. Schichman); the Arkansas Science and Technology Authority (No. 01-B-11); the University of Arkansas for Medical Sciences Medical Research Endowment (Steven A. Schichman); private funding by Donna D. and Donald M. Lambert; and the National Cancer Institute (CA55819) (John Shaughnessy). The authors thank the clinical faculty at MIRT, and Paul Dotson, Sarah Thornton, and Sharon Dobbins at CAVHS for collecting clinical samples. Rebecca Owens and Karen Marshall performed the flow cytometry studies, and Terri Hale provided clerical assistance. The Office of Grants & Publications at UAMS provided assistance with editing and graphics. ",
year = "2003",
month = sep,
day = "1",
doi = "10.1016/S0145-2126(03)00015-8",
language = "English (US)",
volume = "27",
pages = "765--774",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "9",
}