The diagnostic value of rescaled renal biomarkers serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate

Hans Pottel; Laurence Dubourg; Elke Schaeffner; Bjørn Odvar Eriksen; Toralf Melsom; Edmund J. Lamb; Andrew D. Rule; Stephen T. Turner; Richard J. Glassock; Vandréa De Souza; Luciano Selistre; Karolien Goffin; Steven Pauwels; Christophe Mariat; Martin Flamant; Sebastjan Bevc; Pierre Delanaye; Natalie Ebert

doi:10.1016/j.cca.2017.06.005

The diagnostic value of rescaled renal biomarkers serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate

Hans Pottel, Laurence Dubourg, Elke Schaeffner, Bjørn Odvar Eriksen, Toralf Melsom, Edmund J. Lamb, Andrew D. Rule, Stephen T. Turner, Richard J. Glassock, Vandréa De Souza, Luciano Selistre, Karolien Goffin, Steven Pauwels, Christophe Mariat, Martin Flamant, Sebastjan Bevc, Pierre Delanaye, Natalie Ebert

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background Serum creatinine (Scr) is the major contributing variable in glomerular filtration rate (GFR) estimating equations. Serum cystatin C (ScysC) based GFR estimating (eGFR)-equations have also been developed. The present study investigates the relation between ‘rescaled’ levels of these renal biomarkers (with reference interval of [0.67–1.33]) and measured GFR (mGFR). Methods We evaluated the diagnostic ability to detect impaired kidney function of the rescaled renal biomarkers in 8584 subjects from 12 cohorts with measured GFR, standardized Scr and ScysC. We calculated sensitivity and specificity of the rescaled biomarkers to identify kidney disease, with reference to a fixed (60 mL/min/1.73 m²) as well as an age-dependent threshold for mGFR. Results The upper reference limit of 1.33 for rescaled renal biomarkers is closely related to the age-dependent threshold for defining kidney status by mGFR with sensitivity and specificity for the rescaled biomarkers close to 90% for all ages. If the fixed threshold of 60 mL/min/1.73 m² for mGFR is used, then lower specificity in children and sensitivity in older adults are observed. Conclusions Impaired kidney function can be diagnosed by rescaled renal biomarkers instead of eGFR-equations using the fixed threshold of 1.33 for all ages, consistent with an age-dependent threshold of mGFR.

Original language	English (US)
Pages (from-to)	164-170
Number of pages	7
Journal	Clinica Chimica Acta
Volume	471
DOIs	https://doi.org/10.1016/j.cca.2017.06.005
State	Published - Aug 2017

Keywords

Cystatin C
Measured GFR
Serum creatinine

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cca.2017.06.005

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Pottel, H., Dubourg, L., Schaeffner, E., Eriksen, B. O., Melsom, T., Lamb, E. J., Rule, A. D., Turner, S. T., Glassock, R. J., De Souza, V., Selistre, L., Goffin, K., Pauwels, S., Mariat, C., Flamant, M., Bevc, S., Delanaye, P., & Ebert, N. (2017). The diagnostic value of rescaled renal biomarkers serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate. Clinica Chimica Acta, 471, 164-170. https://doi.org/10.1016/j.cca.2017.06.005

Pottel, H, Dubourg, L, Schaeffner, E, Eriksen, BO, Melsom, T, Lamb, EJ, Rule, AD, Turner, ST, Glassock, RJ, De Souza, V, Selistre, L, Goffin, K, Pauwels, S, Mariat, C, Flamant, M, Bevc, S, Delanaye, P & Ebert, N 2017, 'The diagnostic value of rescaled renal biomarkers serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate', Clinica Chimica Acta, vol. 471, pp. 164-170. https://doi.org/10.1016/j.cca.2017.06.005

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title = "The diagnostic value of rescaled renal biomarkers serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate",

abstract = "Background Serum creatinine (Scr) is the major contributing variable in glomerular filtration rate (GFR) estimating equations. Serum cystatin C (ScysC) based GFR estimating (eGFR)-equations have also been developed. The present study investigates the relation between {\textquoteleft}rescaled{\textquoteright} levels of these renal biomarkers (with reference interval of [0.67–1.33]) and measured GFR (mGFR). Methods We evaluated the diagnostic ability to detect impaired kidney function of the rescaled renal biomarkers in 8584 subjects from 12 cohorts with measured GFR, standardized Scr and ScysC. We calculated sensitivity and specificity of the rescaled biomarkers to identify kidney disease, with reference to a fixed (60 mL/min/1.73 m2) as well as an age-dependent threshold for mGFR. Results The upper reference limit of 1.33 for rescaled renal biomarkers is closely related to the age-dependent threshold for defining kidney status by mGFR with sensitivity and specificity for the rescaled biomarkers close to 90% for all ages. If the fixed threshold of 60 mL/min/1.73 m2 for mGFR is used, then lower specificity in children and sensitivity in older adults are observed. Conclusions Impaired kidney function can be diagnosed by rescaled renal biomarkers instead of eGFR-equations using the fixed threshold of 1.33 for all ages, consistent with an age-dependent threshold of mGFR.",

keywords = "Cystatin C, Measured GFR, Serum creatinine",

author = "Hans Pottel and Laurence Dubourg and Elke Schaeffner and Eriksen, {Bj{\o}rn Odvar} and Toralf Melsom and Lamb, {Edmund J.} and Rule, {Andrew D.} and Turner, {Stephen T.} and Glassock, {Richard J.} and {De Souza}, Vandr{\'e}a and Luciano Selistre and Karolien Goffin and Steven Pauwels and Christophe Mariat and Martin Flamant and Sebastjan Bevc and Pierre Delanaye and Natalie Ebert",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = aug,

doi = "10.1016/j.cca.2017.06.005",

language = "English (US)",

volume = "471",

pages = "164--170",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier",

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TY - JOUR

T1 - The diagnostic value of rescaled renal biomarkers serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate

AU - Pottel, Hans

AU - Dubourg, Laurence

AU - Schaeffner, Elke

AU - Eriksen, Bjørn Odvar

AU - Melsom, Toralf

AU - Lamb, Edmund J.

AU - Rule, Andrew D.

AU - Turner, Stephen T.

AU - Glassock, Richard J.

AU - De Souza, Vandréa

AU - Selistre, Luciano

AU - Goffin, Karolien

AU - Pauwels, Steven

AU - Mariat, Christophe

AU - Flamant, Martin

AU - Bevc, Sebastjan

AU - Delanaye, Pierre

AU - Ebert, Natalie

PY - 2017/8

Y1 - 2017/8

N2 - Background Serum creatinine (Scr) is the major contributing variable in glomerular filtration rate (GFR) estimating equations. Serum cystatin C (ScysC) based GFR estimating (eGFR)-equations have also been developed. The present study investigates the relation between ‘rescaled’ levels of these renal biomarkers (with reference interval of [0.67–1.33]) and measured GFR (mGFR). Methods We evaluated the diagnostic ability to detect impaired kidney function of the rescaled renal biomarkers in 8584 subjects from 12 cohorts with measured GFR, standardized Scr and ScysC. We calculated sensitivity and specificity of the rescaled biomarkers to identify kidney disease, with reference to a fixed (60 mL/min/1.73 m2) as well as an age-dependent threshold for mGFR. Results The upper reference limit of 1.33 for rescaled renal biomarkers is closely related to the age-dependent threshold for defining kidney status by mGFR with sensitivity and specificity for the rescaled biomarkers close to 90% for all ages. If the fixed threshold of 60 mL/min/1.73 m2 for mGFR is used, then lower specificity in children and sensitivity in older adults are observed. Conclusions Impaired kidney function can be diagnosed by rescaled renal biomarkers instead of eGFR-equations using the fixed threshold of 1.33 for all ages, consistent with an age-dependent threshold of mGFR.

AB - Background Serum creatinine (Scr) is the major contributing variable in glomerular filtration rate (GFR) estimating equations. Serum cystatin C (ScysC) based GFR estimating (eGFR)-equations have also been developed. The present study investigates the relation between ‘rescaled’ levels of these renal biomarkers (with reference interval of [0.67–1.33]) and measured GFR (mGFR). Methods We evaluated the diagnostic ability to detect impaired kidney function of the rescaled renal biomarkers in 8584 subjects from 12 cohorts with measured GFR, standardized Scr and ScysC. We calculated sensitivity and specificity of the rescaled biomarkers to identify kidney disease, with reference to a fixed (60 mL/min/1.73 m2) as well as an age-dependent threshold for mGFR. Results The upper reference limit of 1.33 for rescaled renal biomarkers is closely related to the age-dependent threshold for defining kidney status by mGFR with sensitivity and specificity for the rescaled biomarkers close to 90% for all ages. If the fixed threshold of 60 mL/min/1.73 m2 for mGFR is used, then lower specificity in children and sensitivity in older adults are observed. Conclusions Impaired kidney function can be diagnosed by rescaled renal biomarkers instead of eGFR-equations using the fixed threshold of 1.33 for all ages, consistent with an age-dependent threshold of mGFR.

KW - Cystatin C

KW - Measured GFR

KW - Serum creatinine

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DO - 10.1016/j.cca.2017.06.005

M3 - Article

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AN - SCOPUS:85020254734

SN - 0009-8981

VL - 471

SP - 164

EP - 170

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

The diagnostic value of rescaled renal biomarkers serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate

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