TY - JOUR
T1 - The diagnosis of thoracic malignant mesothelioma
T2 - Practical considerations and recent developments
AU - Smith, Maxwell
AU - Colby, Thomas
PY - 2014
Y1 - 2014
N2 - Pleural biopsies for the evaluation of malignant mesothelioma can be some of the most challenging cases faced by the practicing surgical pathologist. We review the epidemiology, clinical presentation, and imaging studies in patients with malignant mesothelioma, and then present a practical approach to the diagnosis using the cytologic features for malignancy and whether there is an epithelioid or spindled morphology; four main scenarios are discussed. The pertinent immunohistochemical work-up is reviewed for each scenario. Following this general overview, more unusual histologic patterns are compared and unusual presentations are discussed. Brief mention of grading systems for malignant mesothelioma and the use of electron microscopy and molecular studies is made. Practical considerations in the diagnosis of malignant mesothelioma are made throughout.
AB - Pleural biopsies for the evaluation of malignant mesothelioma can be some of the most challenging cases faced by the practicing surgical pathologist. We review the epidemiology, clinical presentation, and imaging studies in patients with malignant mesothelioma, and then present a practical approach to the diagnosis using the cytologic features for malignancy and whether there is an epithelioid or spindled morphology; four main scenarios are discussed. The pertinent immunohistochemical work-up is reviewed for each scenario. Following this general overview, more unusual histologic patterns are compared and unusual presentations are discussed. Brief mention of grading systems for malignant mesothelioma and the use of electron microscopy and molecular studies is made. Practical considerations in the diagnosis of malignant mesothelioma are made throughout.
KW - Differential diagnosis
KW - Immunohistochemistry
KW - Mesothelioma
KW - Pathology
KW - Thoracic neoplasms
UR - http://www.scopus.com/inward/record.url?scp=84892707310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892707310&partnerID=8YFLogxK
U2 - 10.5146/tjpath.2014.01158
DO - 10.5146/tjpath.2014.01158
M3 - Article
C2 - 24448702
AN - SCOPUS:84892707310
SN - 1018-5615
VL - 30
SP - 1
EP - 10
JO - Turk Patoloji Dergisi/Turkish Journal of Pathology
JF - Turk Patoloji Dergisi/Turkish Journal of Pathology
IS - 1
ER -