The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and dna replicationcoupled nucleosome assembly in budding yeast

Rebecca J. Burgess, Junhong Han, Zhiguo Zhang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Genome stability is maintained in part by chromatin structure and checkpoint factors. Results: Yeast cells harboring mutations in the Ddc1-Mec3-Rad17 checkpoint complex exhibit synthetic phenotypes with histone chaperone mutants. Conclusion: The Ddc1-Mec3-Rad17 complex regulates nucleosome assembly. Significance: Checkpoint factors and histone chaperones coordinate to maintain genome integrity.

Original languageEnglish (US)
Pages (from-to)10518-10529
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number15
DOIs
StatePublished - Apr 11 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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