@article{0aac39c955594d958a65e01db8ee7495,
title = "The DAXX tax: C9orf72 DNA repeat expansions drive gain- and loss-of-function pathology in c9FTD/ALS",
abstract = "In this issue of Neuron, Liu et al.1 identify DAXX as a C9orf72 hexanucleotide repeat expansion DNA-binding protein that initiates epigenetic modifications and chromatin remodeling, contributing to C9orf72 haploinsufficiency by inhibiting its stress-inducible expression and mediating both loss- and toxic gain-of-function pathology.",
author = "Feilin Liu and Wilfried Rossoll",
note = "Funding Information: Generation of this preview was supported by NIH grants RF1 AG068581 , RF1 AG076122 , and R01 AG077771 to W.R. and a Mayo Clinic Center of Biomedical Discovery Pilot Grant to F.L. We thank Melissa Wren for helpful comments in the editing of this manuscript. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",
year = "2023",
month = apr,
day = "19",
doi = "10.1016/j.neuron.2023.03.028",
language = "English (US)",
volume = "111",
pages = "1165--1167",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "8",
}