Abstract
High resolution karyotyping and massive parallel genomic sequencing in mycosis fungoides (MF) and sézary syndrome (SS) have revealed a complex and heterogeneous genomic landscape. Multiple copy number alterations and several DNA sequence mutations are believed to disrupt key intracellular pathways relevant to T-cell and tumor biology, such as T-cell receptor signaling, IL-2/JAK/STAT, NF-κB, MAPK, PI3K/AKT, MYC, TP53, cell cycle checkpoints and epigenetic regulation. Knowledge of the genetic background of cutaneous T-cell lymphoma (CTCL) might contribute to the development of novel targeted therapeutic strategies.
| Original language | English (US) |
|---|---|
| Title of host publication | Cutaneous T-Cell Lymphoma (CTCL) |
| Subtitle of host publication | Clinical Features, Diagnosis and Treatment Options |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 49-56 |
| Number of pages | 8 |
| ISBN (Electronic) | 9781536119190 |
| ISBN (Print) | 9781536118995 |
| State | Published - Jan 1 2017 |
ASJC Scopus subject areas
- General Medicine