High resolution karyotyping and massive parallel genomic sequencing in mycosis fungoides (MF) and sézary syndrome (SS) have revealed a complex and heterogeneous genomic landscape. Multiple copy number alterations and several DNA sequence mutations are believed to disrupt key intracellular pathways relevant to T-cell and tumor biology, such as T-cell receptor signaling, IL-2/JAK/STAT, NF-κB, MAPK, PI3K/AKT, MYC, TP53, cell cycle checkpoints and epigenetic regulation. Knowledge of the genetic background of cutaneous T-cell lymphoma (CTCL) might contribute to the development of novel targeted therapeutic strategies.
|Original language||English (US)|
|Title of host publication||Cutaneous T-Cell Lymphoma (CTCL)|
|Subtitle of host publication||Clinical Features, Diagnosis and Treatment Options|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||8|
|State||Published - Jan 1 2017|
ASJC Scopus subject areas