The cytogenetic and molecular landscape of mycosis fungoides and Sézary syndrome

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

High resolution karyotyping and massive parallel genomic sequencing in mycosis fungoides (MF) and sézary syndrome (SS) have revealed a complex and heterogeneous genomic landscape. Multiple copy number alterations and several DNA sequence mutations are believed to disrupt key intracellular pathways relevant to T-cell and tumor biology, such as T-cell receptor signaling, IL-2/JAK/STAT, NF-κB, MAPK, PI3K/AKT, MYC, TP53, cell cycle checkpoints and epigenetic regulation. Knowledge of the genetic background of cutaneous T-cell lymphoma (CTCL) might contribute to the development of novel targeted therapeutic strategies.

Original languageEnglish (US)
Title of host publicationCutaneous T-Cell Lymphoma (CTCL)
Subtitle of host publicationClinical Features, Diagnosis and Treatment Options
PublisherNova Science Publishers, Inc.
Pages49-56
Number of pages8
ISBN (Electronic)9781536119190
ISBN (Print)9781536118995
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The cytogenetic and molecular landscape of mycosis fungoides and Sézary syndrome'. Together they form a unique fingerprint.

  • Cite this

    Horna, P. (2017). The cytogenetic and molecular landscape of mycosis fungoides and Sézary syndrome. In Cutaneous T-Cell Lymphoma (CTCL): Clinical Features, Diagnosis and Treatment Options (pp. 49-56). Nova Science Publishers, Inc..