TY - JOUR
T1 - The current status of human laryngeal transplantation in 2017
T2 - A state of the field review
AU - Krishnan, Giri
AU - Du, Charles
AU - Fishman, Jonathan M.
AU - Foreman, Andrew
AU - Lott, David G.
AU - Farwell, Gregory
AU - Belafsky, Peter
AU - Krishnan, Suren
AU - Birchall, Martin A.
N1 - Publisher Copyright:
© 2017 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2017/8
Y1 - 2017/8
N2 - Objectives: Human laryngeal allotransplantation has long been contemplated as a surgical option following laryngectomy, but there is a paucity of information regarding the indications, surgical procedure, and patient outcomes. Our objectives were to identify all human laryngeal allotransplants that have been undertaken and reported in the English literature and to evaluate the success of the procedure. Data Sources: MEDLINE, Embase, Current Index to Nursing and Allied Health Literature, Web of Science and Scopus, and the Gray literature. Review Methods: A comprehensive search strategy was undertaken across multiple databases. Inclusion criteria were case reports of patients who had undergone human laryngeal allotransplantation. Information regarding indications, operative techniques, complications, graft viability, and functional outcomes were extracted. Results: A total of 5,961 articles, following removal of duplicates, matched the search criteria and were screened, with five case reports relating to two patients, ultimately fulfilling the entry criteria. Conclusions: Two laryngeal transplants have been reported in the medical literature. Although both patients report improved quality of life relating to their ability to communicate with voice, further research is necessary to shape our understanding of this complicated operation, its indications, and its functional outcomes. Laryngoscope, 127:1861–1868, 2017.
AB - Objectives: Human laryngeal allotransplantation has long been contemplated as a surgical option following laryngectomy, but there is a paucity of information regarding the indications, surgical procedure, and patient outcomes. Our objectives were to identify all human laryngeal allotransplants that have been undertaken and reported in the English literature and to evaluate the success of the procedure. Data Sources: MEDLINE, Embase, Current Index to Nursing and Allied Health Literature, Web of Science and Scopus, and the Gray literature. Review Methods: A comprehensive search strategy was undertaken across multiple databases. Inclusion criteria were case reports of patients who had undergone human laryngeal allotransplantation. Information regarding indications, operative techniques, complications, graft viability, and functional outcomes were extracted. Results: A total of 5,961 articles, following removal of duplicates, matched the search criteria and were screened, with five case reports relating to two patients, ultimately fulfilling the entry criteria. Conclusions: Two laryngeal transplants have been reported in the medical literature. Although both patients report improved quality of life relating to their ability to communicate with voice, further research is necessary to shape our understanding of this complicated operation, its indications, and its functional outcomes. Laryngoscope, 127:1861–1868, 2017.
KW - Larynx
KW - transplant recipients
KW - transplantation
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U2 - 10.1002/lary.26503
DO - 10.1002/lary.26503
M3 - Article
C2 - 28224630
AN - SCOPUS:85013498701
SN - 0023-852X
VL - 127
SP - 1861
EP - 1868
JO - Laryngoscope
JF - Laryngoscope
IS - 8
ER -