The crosstalk between acinar cells with Kras mutations and M1-polarized macrophages leads to initiation of pancreatic precancerous lesions

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4 Scopus citations

Abstract

Recent studies on the processes that lead to the development of pancreatic cancer indicate that inflammatory macrophages have key functions in the initiation of pre-neoplastic lesions. Specifically, acquisition of an activating Kras mutation in pancreatic acinar cells leads to upregulation of intercellular adhesion molecule-1 (ICAM-1), which serves as a chemoattractant for M1-polarized macrophages. M1 macrophages then contribute to acinar cell metaplasia and development of precancerous lesions through inflammatory cytokines and secreted proteases.

Original languageEnglish (US)
JournalOncoImmunology
Volume4
Issue number6
DOIs
StatePublished - Jan 1 2015

Keywords

  • Acinar-to-ductal metaplasia
  • Inflammation
  • Kras
  • Macrophages
  • Pancreas
  • Pancreatic cancer
  • Pancreatitis
  • PanIN

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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