Abstract
Recent studies on the processes that lead to the development of pancreatic cancer indicate that inflammatory macrophages have key functions in the initiation of pre-neoplastic lesions. Specifically, acquisition of an activating Kras mutation in pancreatic acinar cells leads to upregulation of intercellular adhesion molecule-1 (ICAM-1), which serves as a chemoattractant for M1-polarized macrophages. M1 macrophages then contribute to acinar cell metaplasia and development of precancerous lesions through inflammatory cytokines and secreted proteases.
Original language | English (US) |
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Journal | OncoImmunology |
Volume | 4 |
Issue number | 6 |
DOIs | |
State | Published - Jan 1 2015 |
Keywords
- Acinar-to-ductal metaplasia
- Inflammation
- Kras
- Macrophages
- PanIN
- Pancreas
- Pancreatic cancer
- Pancreatitis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology