The crosstalk between acinar cells with Kras mutations and M1-polarized macrophages leads to initiation of pancreatic precancerous lesions

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3 Citations (Scopus)

Abstract

Recent studies on the processes that lead to the development of pancreatic cancer indicate that inflammatory macrophages have key functions in the initiation of pre-neoplastic lesions. Specifically, acquisition of an activating Kras mutation in pancreatic acinar cells leads to upregulation of intercellular adhesion molecule-1 (ICAM-1), which serves as a chemoattractant for M1-polarized macrophages. M1 macrophages then contribute to acinar cell metaplasia and development of precancerous lesions through inflammatory cytokines and secreted proteases.

Original languageEnglish (US)
JournalOncoImmunology
Volume4
Issue number6
DOIs
StatePublished - Jan 1 2015

Fingerprint

Acinar Cells
Macrophages
Mutation
Chemotactic Factors
Metaplasia
Intercellular Adhesion Molecule-1
Pancreatic Neoplasms
Peptide Hydrolases
Up-Regulation
Cytokines

Keywords

  • Acinar-to-ductal metaplasia
  • Inflammation
  • Kras
  • Macrophages
  • Pancreas
  • Pancreatic cancer
  • Pancreatitis
  • PanIN

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

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title = "The crosstalk between acinar cells with Kras mutations and M1-polarized macrophages leads to initiation of pancreatic precancerous lesions",
abstract = "Recent studies on the processes that lead to the development of pancreatic cancer indicate that inflammatory macrophages have key functions in the initiation of pre-neoplastic lesions. Specifically, acquisition of an activating Kras mutation in pancreatic acinar cells leads to upregulation of intercellular adhesion molecule-1 (ICAM-1), which serves as a chemoattractant for M1-polarized macrophages. M1 macrophages then contribute to acinar cell metaplasia and development of precancerous lesions through inflammatory cytokines and secreted proteases.",
keywords = "Acinar-to-ductal metaplasia, Inflammation, Kras, Macrophages, Pancreas, Pancreatic cancer, Pancreatitis, PanIN",
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AB - Recent studies on the processes that lead to the development of pancreatic cancer indicate that inflammatory macrophages have key functions in the initiation of pre-neoplastic lesions. Specifically, acquisition of an activating Kras mutation in pancreatic acinar cells leads to upregulation of intercellular adhesion molecule-1 (ICAM-1), which serves as a chemoattractant for M1-polarized macrophages. M1 macrophages then contribute to acinar cell metaplasia and development of precancerous lesions through inflammatory cytokines and secreted proteases.

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KW - Pancreatitis

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