The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

S. Bamford, E. Dawson, S. Forbes, J. Clements, R. Pettett, A. Dogan, A. Flanagan, J. Teague, P. A. Futreal, M. R. Stratton, R. Wooster

Research output: Contribution to journalArticle

679 Citations (Scopus)

Abstract

The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.

Original languageEnglish (US)
Pages (from-to)355-358
Number of pages4
JournalBritish Journal of Cancer
Volume91
Issue number2
StatePublished - Jul 19 2004
Externally publishedYes

Fingerprint

Databases
Mutation
Neoplasms
Literature
Data Display
Neoplasm Genes
Human Genome
Genes

Keywords

  • Database
  • Mutation
  • Somatic
  • Website

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bamford, S., Dawson, E., Forbes, S., Clements, J., Pettett, R., Dogan, A., ... Wooster, R. (2004). The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. British Journal of Cancer, 91(2), 355-358.

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. / Bamford, S.; Dawson, E.; Forbes, S.; Clements, J.; Pettett, R.; Dogan, A.; Flanagan, A.; Teague, J.; Futreal, P. A.; Stratton, M. R.; Wooster, R.

In: British Journal of Cancer, Vol. 91, No. 2, 19.07.2004, p. 355-358.

Research output: Contribution to journalArticle

Bamford, S, Dawson, E, Forbes, S, Clements, J, Pettett, R, Dogan, A, Flanagan, A, Teague, J, Futreal, PA, Stratton, MR & Wooster, R 2004, 'The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website', British Journal of Cancer, vol. 91, no. 2, pp. 355-358.
Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A et al. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. British Journal of Cancer. 2004 Jul 19;91(2):355-358.
Bamford, S. ; Dawson, E. ; Forbes, S. ; Clements, J. ; Pettett, R. ; Dogan, A. ; Flanagan, A. ; Teague, J. ; Futreal, P. A. ; Stratton, M. R. ; Wooster, R. / The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. In: British Journal of Cancer. 2004 ; Vol. 91, No. 2. pp. 355-358.
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