The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

S. Bamford; E. Dawson; S. Forbes; J. Clements; R. Pettett; A. Dogan; A. Flanagan; J. Teague; P. A. Futreal; M. R. Stratton; R. Wooster

doi:10.1038/sj.bjc.6601894

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

S. Bamford, E. Dawson, S. Forbes, J. Clements, R. Pettett, A. Dogan, A. Flanagan, J. Teague, P. A. Futreal, M. R. Stratton, R. Wooster

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

782 Scopus citations

Abstract

The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.

Original language	English (US)
Pages (from-to)	355-358
Number of pages	4
Journal	British journal of cancer
Volume	91
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6601894
State	Published - Jul 19 2004

Keywords

Database
Mutation
Somatic
Website

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/sj.bjc.6601894

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title = "The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website",

abstract = "The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.",

keywords = "Database, Mutation, Somatic, Website",

author = "S. Bamford and E. Dawson and S. Forbes and J. Clements and R. Pettett and A. Dogan and A. Flanagan and J. Teague and Futreal, {P. A.} and Stratton, {M. R.} and R. Wooster",

note = "Funding Information: We thank Frances Martin and the Institute of Cancer Research and The Wellcome Trust for funding this work.",

year = "2004",

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doi = "10.1038/sj.bjc.6601894",

language = "English (US)",

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AU - Bamford, S.

AU - Dawson, E.

AU - Forbes, S.

AU - Clements, J.

AU - Pettett, R.

AU - Dogan, A.

AU - Flanagan, A.

AU - Teague, J.

AU - Futreal, P. A.

AU - Stratton, M. R.

AU - Wooster, R.

N1 - Funding Information: We thank Frances Martin and the Institute of Cancer Research and The Wellcome Trust for funding this work.

PY - 2004/7/19

Y1 - 2004/7/19

N2 - The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.

AB - The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.

KW - Database

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KW - Somatic

KW - Website

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The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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