The concept of pharmacologic cocaine interception as a treatment for drug abuse

Yang Gao, Frank M. Orson, Berma Kinsey, Tom Kosten, Stephen Brimijoin

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Cocaine access to brain tissue and associated cocaine-induced behaviors are substantially reduced in rats and mice by significant plasma levels of an enzyme that rapidly metabolizes the drug. Similar results have been obtained in rodents and humans with therapeutic anti-cocaine antibodies, which sequester the drug and prevent its entry into the brain. We show that an efficient cocaine hydrolase can lead to rapid unloading of anti-cocaine antibodies saturated with cocaine, and we provide a theoretical basis for the hypothesis that dual therapy with antibody and hydrolase enzyme may be especially effective.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalChemico-biological interactions
Volume187
Issue number1-3
DOIs
StatePublished - Sep 2010

Keywords

  • Anti-cocaine-antibody
  • Butyrylcholinesterase
  • Cocaine hydrolase
  • Cocaine vaccine

ASJC Scopus subject areas

  • Toxicology

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