The combination of patient-reported clinical symptoms and an endoscopic score correlates well with health-related quality of life in patients with ulcerative colitis

Satimai Aniwan, David H Bruining, Sang Hyoung Park, Badr Al-Bawardy, Sunanda V. Kane, Nayantara Coelho Prabhu, John B. Kisiel, Laura E. H. Raffals, Konstantinos Papadakis, Darrell Spencer Pardi, William J. Tremaine, Edward Vincent Loftus, Jr

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Patient-reported outcomes (PROs) will become increasingly important as primary endpoints in future clinical trials. We aimed to evaluate the relationship between health-related quality of life (HRQoL) and the combination of patient-reported clinical symptoms (ClinPRO2) and Mayo endoscopic subscore (MES) in patients with ulcerative colitis (UC). Methods: We conducted a prospective cross-sectional study of 90 consecutive UC patients who were scheduled for sigmoidoscopy or colonoscopy. All patients completed the following questionnaires: (1) self-rated rectal bleeding and stool frequency (ClinPRO2); (2) Short Inflammatory Bowel Disease Questionnaire (SIBDQ); (3) European Quality of Life 5-Dimensions 3-Level (EQ5D3L); (4) Work Productivity and Activity Impairment questionnaire (WPAI); (5) Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); and (6) Hospital Anxiety and Depression Scale (HADS). The endoscopic images were graded according to the MES. “No symptoms” was defined as a symptom score of 0, and “mucosal healing” was defined as MES score of 0–1. Correlations between the combined ClinPRO2 and MES with HRQoL were assessed using Spearman’s correlation coefficients. Results: The combination of the ClinPRO2 and MES was well correlated to SIBDQ (r = −0.70), EQ5D3L (r = −0.51), WPAI (r = 0.62), FACIT-F (r = −0.58), and HADS-depression (r = 0.45). SIBDQ scores had strong correlations with FACIT-F (r = 0.86), WPAI (r = −0.80), and HADS-depression (r = −0.75) (p < 0.05 for all correlations). Patients with no symptoms reported the greatest all HRQoL scores. Conclusions: In patients with ulcerative colitis, the combination of a ClinPRO2 and the MES had good correlation with the SIBDQ. In addition, SIBDQ was well correlated to the various HRQoL.

Original languageEnglish (US)
Article number1171
JournalJournal of Clinical Medicine
Volume8
Issue number8
DOIs
StatePublished - Aug 2019

Keywords

  • Endoscopy
  • Outcome
  • Quality of life
  • Ulcerative colitis

ASJC Scopus subject areas

  • Medicine(all)

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