TY - JOUR
T1 - The coexistence of peripheral nerve sheath tumors and vitiligo
T2 - more than coincidence?
AU - Elsherif, Mohamed A.
AU - Spinner, Robert J.
AU - Miest, Rachel Y.
N1 - Publisher Copyright:
© 2015, Springer-Verlag Wien.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Neurocristopathies arise from abnormal migration, differentiation, or proliferation of neural crest derivatives, leading to diverse clinical and pathological features. They are classified into dysgenetic or neoplastic, and can affect single or multiple sites (simple versus complex). Examples include congenital melanocytic nevi, neuroblastoma, Hirshsprung’s disease, Waardenburg’s syndrome, neurofibromatosis (NF) 1 and multiple endocrine neoplasia (MEN) 2A and 2B. We report two cases of peripheral nerve sheath tumors associated with vitiligo and discuss the possible implicated embryologic, genetic and molecular mechanisms. To our knowledge, we also report the first case of de novo malignant peripheral nerve sheath tumor (MPNST) associated with vitiligo.
AB - Neurocristopathies arise from abnormal migration, differentiation, or proliferation of neural crest derivatives, leading to diverse clinical and pathological features. They are classified into dysgenetic or neoplastic, and can affect single or multiple sites (simple versus complex). Examples include congenital melanocytic nevi, neuroblastoma, Hirshsprung’s disease, Waardenburg’s syndrome, neurofibromatosis (NF) 1 and multiple endocrine neoplasia (MEN) 2A and 2B. We report two cases of peripheral nerve sheath tumors associated with vitiligo and discuss the possible implicated embryologic, genetic and molecular mechanisms. To our knowledge, we also report the first case of de novo malignant peripheral nerve sheath tumor (MPNST) associated with vitiligo.
KW - Malignant peripheral nerve sheath tumors
KW - Neurocristopathies
KW - Peripheral nerve sheath tumors
KW - Schwannoma
KW - Vitiligo
UR - http://www.scopus.com/inward/record.url?scp=84951906500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951906500&partnerID=8YFLogxK
U2 - 10.1007/s00701-015-2629-8
DO - 10.1007/s00701-015-2629-8
M3 - Article
C2 - 26607956
AN - SCOPUS:84951906500
SN - 0001-6268
VL - 158
SP - 95
EP - 99
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
IS - 1
ER -