TY - JOUR
T1 - The clinician's guide to the anti-vaccinationists' galaxy
AU - Poland, Gregory A.
AU - Jacobson, Robert M.
N1 - Funding Information:
Dr. Poland is the chair of a Safety Evaluation Committee for investigational vaccine trials being conducted by Merck Research Laboratories. Dr. Poland offers consultative advice on new vaccine development to Merck & Co., Inc., Avianax, Theraclone Sciences (formally Spaltudaq Corporation), MedImmune LLC, Liquidia Technologies, Inc., Emergent BioSolutions, Novavax, Dynavax, EMD Serono, Inc., Novartis Vaccines and Therapeutics and PAXVAX, Inc. Dr. Jacobson is a member of a safety review committee for a post-licensure study funded by Merck & Co. concerning the safety of a human papillomavirus vaccine. He is also a member of a data monitoring committee for an investigational vaccine trial funded by Merck & Co. He also serves as a principal investigator for two studies, including one funded by Novartis International for its licensed meningococcal conjugate vaccine and one funded by Pfizer, Inc. for its licensed pneumococcal conjugate vaccine.
PY - 2012/8
Y1 - 2012/8
N2 - In this paper we briefly review three common immunological misconceptions that feature prominently among anti-vaccinationists, and in turn, fuel patient and parental concerns, questions, and fears about vaccines. In particular, this Perspective covers a brief history of the anti-vaccine movement, and three common false immunological claims, namely, concerns over " antigenic overload," the induction of autoimmunity by vaccines, and the value of " natural immunity" versus vaccine-induced immunity. This is followed by a review of the harms that have been done by anti-vaccinationists, and a call to action. Regardless of the motivation behind such fears and anti-vaccine sentiment, common fears and concerns relevant to vaccines are evident and therefore are the subject of this Perspective. It is hoped that clinicians will find this information useful in answering concerns and misconceptions about vaccines, and in educating their patients.
AB - In this paper we briefly review three common immunological misconceptions that feature prominently among anti-vaccinationists, and in turn, fuel patient and parental concerns, questions, and fears about vaccines. In particular, this Perspective covers a brief history of the anti-vaccine movement, and three common false immunological claims, namely, concerns over " antigenic overload," the induction of autoimmunity by vaccines, and the value of " natural immunity" versus vaccine-induced immunity. This is followed by a review of the harms that have been done by anti-vaccinationists, and a call to action. Regardless of the motivation behind such fears and anti-vaccine sentiment, common fears and concerns relevant to vaccines are evident and therefore are the subject of this Perspective. It is hoped that clinicians will find this information useful in answering concerns and misconceptions about vaccines, and in educating their patients.
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U2 - 10.1016/j.humimm.2012.03.014
DO - 10.1016/j.humimm.2012.03.014
M3 - Review article
C2 - 22504410
AN - SCOPUS:84864059048
SN - 0198-8859
VL - 73
SP - 859
EP - 866
JO - Human Immunology
JF - Human Immunology
IS - 8
ER -