TY - JOUR
T1 - The Clinical Syndrome of Striatal Dopamine Deficiency
T2 - Parkinsonism Induced by MPTP
AU - Eldridge, Roswell
AU - Rocca, Walter A.
PY - 1985/10/31
Y1 - 1985/10/31
N2 - To the Editor: The suggestion has been made in the Journal1 and elsewhere2 that a neurotoxin such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) may be the cause of Parkinson's disease. However, Burns et al. (May 30 issue)3 find that differences in central noradrenergic activity distinguish MPTP-induced parkinsonism from Parkinson's disease. We think it is important for those responsible for the direction of research on Parkinson's disease to be aware of several additional observations suggesting that MPTP is not the cause of the disease. The first and most telling observation concerns the uniform distribution and relatively stable occurrence of this disease over a period.
AB - To the Editor: The suggestion has been made in the Journal1 and elsewhere2 that a neurotoxin such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) may be the cause of Parkinson's disease. However, Burns et al. (May 30 issue)3 find that differences in central noradrenergic activity distinguish MPTP-induced parkinsonism from Parkinson's disease. We think it is important for those responsible for the direction of research on Parkinson's disease to be aware of several additional observations suggesting that MPTP is not the cause of the disease. The first and most telling observation concerns the uniform distribution and relatively stable occurrence of this disease over a period.
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U2 - 10.1056/NEJM198510313131813
DO - 10.1056/NEJM198510313131813
M3 - Letter
C2 - 3876508
AN - SCOPUS:0022357305
SN - 0028-4793
VL - 313
SP - 1159
EP - 1160
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 18
ER -