The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease

Siri A. Urquhart; Kevin P. Quinn; Karthik Ravi; Edward V. Loftus

doi:10.1093/crocol/otab018

The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease

Siri A. Urquhart, Kevin P. Quinn, Karthik Ravi, Edward V. Loftus

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The clinical characteristics and treatment outcomes in patients with eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) have not been extensively investigated. Methods: We determined treatment outcomes and frequencies of disease-related complications in patients with EoE and IBD. Results: Among 69 patients who met inclusion criteria, 39 (56.5%) had a diagnosis of Crohn disease. Clinical and histologic response rates to proton pump inhibitors and topical steroids were 25.9% and 24.4%, respectively. Conclusions: Lower than expected clinical and histologic response rates for EoE suggest the combination of EoE and IBD is a medically refractory phenotype with more difficult to treat EoE.

Original language	English (US)
Article number	otab018
Journal	Crohn's and Colitis 360
Volume	3
Issue number	2
DOIs	https://doi.org/10.1093/crocol/otab018
State	Published - Apr 1 2021

Keywords

Crohn disease
eosinophilic esophagitis
indeterminate colitis
ulcerative colitis

ASJC Scopus subject areas

Gastroenterology

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10.1093/crocol/otab018

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abstract = "Background: The clinical characteristics and treatment outcomes in patients with eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) have not been extensively investigated. Methods: We determined treatment outcomes and frequencies of disease-related complications in patients with EoE and IBD. Results: Among 69 patients who met inclusion criteria, 39 (56.5%) had a diagnosis of Crohn disease. Clinical and histologic response rates to proton pump inhibitors and topical steroids were 25.9% and 24.4%, respectively. Conclusions: Lower than expected clinical and histologic response rates for EoE suggest the combination of EoE and IBD is a medically refractory phenotype with more difficult to treat EoE.",

keywords = "Crohn disease, eosinophilic esophagitis, indeterminate colitis, ulcerative colitis",

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AU - Urquhart, Siri A.

AU - Quinn, Kevin P.

AU - Ravi, Karthik

AU - Loftus, Edward V.

PY - 2021/4/1

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AB - Background: The clinical characteristics and treatment outcomes in patients with eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) have not been extensively investigated. Methods: We determined treatment outcomes and frequencies of disease-related complications in patients with EoE and IBD. Results: Among 69 patients who met inclusion criteria, 39 (56.5%) had a diagnosis of Crohn disease. Clinical and histologic response rates to proton pump inhibitors and topical steroids were 25.9% and 24.4%, respectively. Conclusions: Lower than expected clinical and histologic response rates for EoE suggest the combination of EoE and IBD is a medically refractory phenotype with more difficult to treat EoE.

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KW - indeterminate colitis

KW - ulcerative colitis

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The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease

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Keywords

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