The chronology of Graves' ophthalmopathy in an incidence cohort

G. B. Bartley, V. Fatourechi, E. F. Kadrmas, S. J. Jacobsen, D. M. Ilstrup, J. A. Garrity, C. A. Gorman

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Abstract

PURPOSE: To determine the chronologic characteristics of Graves' ophthalmopathy in an incidence cohort of 120 patients. METHODS: We reviewed the community medical records of 120 patients residing in Olmsted County, Minnesota, in whom Graves' ophthalmopathy had been diagnosed between 1976 and 1990. RESULTS: Median age at the time of diagnosis of Graves' ophthalmopathy was 43 years; the minimum and maximum ages were 8 and 88 years, respectively. Among 108 patients with hyperthyroidism, ophthalmopathy was diagnosed in the six-month interval preceding the diagnosis of thyroid dysfunction in 20 patients (18.5%); ophthalmopathy was concurrent with the diagnosis of hyperthyroidism in 22 patients (20.3%); and ophthalmopathy developed in the six-month interval after thyroid diagnosis in 24 patients (22.2%). Ophthalmopathy was diagnosed more than six months before the diagnosis of hyperthyroidism in only four additional patients (3.7%), whereas ocular changes developed six months or more after thyroid disease in the remaining 38 patients (35.2%). There was no significant seasonal variation in the diagnosis of either thyroid dysfunction or ophthalmopathy. Treatment of hyperthyroidism with iodine-131 did not appear to influence the course of Graves' ophthalmopathy. CONCLUSIONS: There is a strong temporal relationship between the thyroid and eye manifestations of Graves' disease. The diagnosis of Graves' ophthalmopathy tends to follow the diagnosis of hyperthyroidism. Treatment with iodine-131 does not appear to influence the course of Graves' ophthalmopathy. Although both childhood Graves' disease and Graves' ophthalmopathy are uncommon, ophthalmopathy occurs at all ages.

Original languageEnglish (US)
Pages (from-to)426-434
Number of pages9
JournalAmerican journal of ophthalmology
Volume121
Issue number4
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Ophthalmology

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    Bartley, G. B., Fatourechi, V., Kadrmas, E. F., Jacobsen, S. J., Ilstrup, D. M., Garrity, J. A., & Gorman, C. A. (1996). The chronology of Graves' ophthalmopathy in an incidence cohort. American journal of ophthalmology, 121(4), 426-434. https://doi.org/10.1016/S0002-9394(14)70439-8