The changing incidence of oesophageal and gastric adenocarcinoma by anatomic sub-site

S. J. Crane, G. Richard Locke, W. S. Harmsen, N. N. Diehl, A. R. Zinsmeister, L. Joseph Melton, Y. Romero, N. J. Talley

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Background: The incidence rates of gastric and oesophageal adenocarcinoma are changing significantly, but little is known about specific sub-sites. Aim: To use a population-based approach to describe the trends in the site-specific incidence of oesophageal and gastric adenocarcinoma. Methods: Using the Rochester Epidemiology Project, all cases of gastric and oesophageal adenocarcinoma among Olmsted County, Minnesota, residents first diagnosed between 1971 and 2000 were identified (n = 186). Complete in-patient and out-patient records were reviewed and site determined from pathological, surgical, endoscopic and radiological reports. Results: Between the decades of 1971-1980 and 1991-2000, the incidence of oesophageal adenocarcinoma increased significantly from 0.4 to 2.5 per 100 000 person-years. The incidence of adenocarcinoma of the oesophagogastric junction also increased from a rate of 0.6 to 2.2 per 100 000 person-years. The incidence rate of cancer involving the gastric cardia was stable but the incidence of adenocarcinoma involving distal gastric sites declined. Combined oesophageal and oesophagogastric junction adenocarcinoma (4.7 per 1 000 000 person-years) was as common as gastric adenocarcinoma (3.4 per 100 000 person-years) in 1991-2000. Conclusions: The incidence rates of adenocarcinoma involving proximal gastric sub-sites do not appear to be increasing in a manner similar to those involving oesophageal sub-sites.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume25
Issue number4
DOIs
StatePublished - Feb 2007

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Crane, S. J., Richard Locke, G., Harmsen, W. S., Diehl, N. N., Zinsmeister, A. R., Joseph Melton, L., Romero, Y., & Talley, N. J. (2007). The changing incidence of oesophageal and gastric adenocarcinoma by anatomic sub-site. Alimentary Pharmacology and Therapeutics, 25(4), 447-453. https://doi.org/10.1111/j.1365-2036.2006.03229.x