The challenge of treating biofilm-associated bacterial infections

J. L. Del Pozo, Robin Patel

Research output: Contribution to journalArticle

316 Citations (Scopus)

Abstract

Biofilm formation is a crucial step in the pathogenesis of many subacute and chronic bacterial infections, including foreign body-related infections. Biofilms are difficult to eradicate with conventional antimicrobial agents. Bacterial biofilms have several potential antimicrobial resistance mechanisms. Antimicrobial resistance mechanisms may act concurrently, and in some cases, synergistically. Persister cells play a major role in the tolerance of biofilm bacteria to antimicrobial agents. Understanding the mechanisms involved in biofilm-associated antimicrobial resistance is key to development of new therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)204-209
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume82
Issue number2
DOIs
StatePublished - Aug 2007

Fingerprint

Biofilms
Bacterial Infections
Anti-Infective Agents
Foreign Bodies
Bacteria
Infection
Therapeutics

ASJC Scopus subject areas

  • Pharmacology

Cite this

The challenge of treating biofilm-associated bacterial infections. / Del Pozo, J. L.; Patel, Robin.

In: Clinical Pharmacology and Therapeutics, Vol. 82, No. 2, 08.2007, p. 204-209.

Research output: Contribution to journalArticle

@article{8f775c8696b44a199e88d2fc45b33073,
title = "The challenge of treating biofilm-associated bacterial infections",
abstract = "Biofilm formation is a crucial step in the pathogenesis of many subacute and chronic bacterial infections, including foreign body-related infections. Biofilms are difficult to eradicate with conventional antimicrobial agents. Bacterial biofilms have several potential antimicrobial resistance mechanisms. Antimicrobial resistance mechanisms may act concurrently, and in some cases, synergistically. Persister cells play a major role in the tolerance of biofilm bacteria to antimicrobial agents. Understanding the mechanisms involved in biofilm-associated antimicrobial resistance is key to development of new therapeutic strategies.",
author = "{Del Pozo}, {J. L.} and Robin Patel",
year = "2007",
month = "8",
doi = "10.1038/sj.clpt.6100247",
language = "English (US)",
volume = "82",
pages = "204--209",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - The challenge of treating biofilm-associated bacterial infections

AU - Del Pozo, J. L.

AU - Patel, Robin

PY - 2007/8

Y1 - 2007/8

N2 - Biofilm formation is a crucial step in the pathogenesis of many subacute and chronic bacterial infections, including foreign body-related infections. Biofilms are difficult to eradicate with conventional antimicrobial agents. Bacterial biofilms have several potential antimicrobial resistance mechanisms. Antimicrobial resistance mechanisms may act concurrently, and in some cases, synergistically. Persister cells play a major role in the tolerance of biofilm bacteria to antimicrobial agents. Understanding the mechanisms involved in biofilm-associated antimicrobial resistance is key to development of new therapeutic strategies.

AB - Biofilm formation is a crucial step in the pathogenesis of many subacute and chronic bacterial infections, including foreign body-related infections. Biofilms are difficult to eradicate with conventional antimicrobial agents. Bacterial biofilms have several potential antimicrobial resistance mechanisms. Antimicrobial resistance mechanisms may act concurrently, and in some cases, synergistically. Persister cells play a major role in the tolerance of biofilm bacteria to antimicrobial agents. Understanding the mechanisms involved in biofilm-associated antimicrobial resistance is key to development of new therapeutic strategies.

UR - http://www.scopus.com/inward/record.url?scp=34447554517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447554517&partnerID=8YFLogxK

U2 - 10.1038/sj.clpt.6100247

DO - 10.1038/sj.clpt.6100247

M3 - Article

C2 - 17538551

AN - SCOPUS:34447554517

VL - 82

SP - 204

EP - 209

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 2

ER -