TY - JOUR
T1 - The challenge of modeling macular degeneration in mice
AU - Marmorstein, Alan D.
AU - Marmorstein, Lihua Y.
N1 - Funding Information:
We are grateful to Benjamin Bakall and Catherine Bowes-Rickman for their critical reading of the manuscript; to Muna Naash for her comments on the manuscript and for sharing unpublished material; to Christine Curcio for critically reading the manuscript; and to Mathew LaVail for helpful discussions. Work in the authors’ laboratories is funded by the NIH (EY13160, EY13847, and EY14898), Phillip Morris USA and Phillip Morris International, the Macular Vision Research Foundation, and Research to Prevent Blindness.
PY - 2007/5
Y1 - 2007/5
N2 - Macular degenerations (MD), age-related or inherited, interfere with the ability to read, drive and recognize faces. Understanding this class of diseases has been challenging because the mouse, the mammal most amenable to genetic manipulation, lacks a macula. Here we discuss whether we can model MD in the mouse, present criteria for an 'ideal' mouse model of MD and discuss how mouse models have contributed to our knowledge of MD by contrasting how well they meet the 'ideal' criteria with how informative they have actually been. By modeling MD in mice, we can learn about aspects of MD that an animal with a macula would be unable to teach us.
AB - Macular degenerations (MD), age-related or inherited, interfere with the ability to read, drive and recognize faces. Understanding this class of diseases has been challenging because the mouse, the mammal most amenable to genetic manipulation, lacks a macula. Here we discuss whether we can model MD in the mouse, present criteria for an 'ideal' mouse model of MD and discuss how mouse models have contributed to our knowledge of MD by contrasting how well they meet the 'ideal' criteria with how informative they have actually been. By modeling MD in mice, we can learn about aspects of MD that an animal with a macula would be unable to teach us.
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U2 - 10.1016/j.tig.2007.03.001
DO - 10.1016/j.tig.2007.03.001
M3 - Article
C2 - 17368622
AN - SCOPUS:34247257159
SN - 0168-9525
VL - 23
SP - 225
EP - 231
JO - Trends in Genetics
JF - Trends in Genetics
IS - 5
ER -