TY - JOUR
T1 - The cell cycle inhibitors p21(WAF1) and p27(KIP1) are associated with survival in patients treated by salvage prostatectomy after radiation therapy
AU - Cheng, Liang
AU - Lloyd, Ricardo V.
AU - Weaver, Amy L.
AU - Pisansky, Thomas M.
AU - Cheville, John C.
AU - Ramnani, Dharamdas M.
AU - Leibovich, Bradley C.
AU - Blute, Michael L.
AU - Zincke, Horst
AU - Bostwich, David G.
PY - 2000/5
Y1 - 2000/5
N2 - We evaluated p27(KIP1) and p21(WAF1) expression in 52 patients treated by salvage radical prostatectomy and bilateral pelvic lymphadenectomy for biopsy-proven locally persistent or recurrent prostate cancer after external beam radiation therapy. We defined low and high expression based on the median value observed in our sample. Five-year distant metastasis-free survival and cancer-specific survival were 71 and 82%, respectively, for patients with low expression of p21 (≤5%), compared with 94 and 100%, respectively, for those with high expression of p21 (>5%; P = 0.02 and 0.01, respectively). Five-year distant metastasis-free survival and cancer-specific survival were 71 and 82%, respectively, for patients with low expression of p27 (<50%), compared with 88 and 96%, respectively, for those with high expression of p27 (≥50%; P = 0.06 and 0.01, respectively). These findings indicate that p21 and p27 expression levels are significant predictors of survival for patients selected for salvage prostatectomy for recurrent prostate cancer.
AB - We evaluated p27(KIP1) and p21(WAF1) expression in 52 patients treated by salvage radical prostatectomy and bilateral pelvic lymphadenectomy for biopsy-proven locally persistent or recurrent prostate cancer after external beam radiation therapy. We defined low and high expression based on the median value observed in our sample. Five-year distant metastasis-free survival and cancer-specific survival were 71 and 82%, respectively, for patients with low expression of p21 (≤5%), compared with 94 and 100%, respectively, for those with high expression of p21 (>5%; P = 0.02 and 0.01, respectively). Five-year distant metastasis-free survival and cancer-specific survival were 71 and 82%, respectively, for patients with low expression of p27 (<50%), compared with 88 and 96%, respectively, for those with high expression of p27 (≥50%; P = 0.06 and 0.01, respectively). These findings indicate that p21 and p27 expression levels are significant predictors of survival for patients selected for salvage prostatectomy for recurrent prostate cancer.
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M3 - Article
C2 - 10815913
AN - SCOPUS:0034109296
SN - 1078-0432
VL - 6
SP - 1896
EP - 1899
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 5
ER -