The cell biology of the hepatocyte: A membrane trafficking machine

Ryan J. Schulze, Micah B. Schott, Carol A. Casey, Pamela L. Tuma, Mark A Mc Niven

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The liver performs numerous vital functions, including the detoxification of blood before access to the brain while simultaneously secreting and internalizing scores of proteins and lipids to maintain appropriate blood chemistry. Furthermore, the liver also synthesizes and secretes bile to enable the digestion of food. These diverse attributes are all performed by hepatocytes, the parenchymal cells of the liver. As predicted, these cells possess a remarkably well-developed and complex membrane trafficking machinery that is dedicated to moving specific cargos to their correct cellular locations. Importantly, while most epithelial cells secrete nascent proteins directionally toward a single lumen, the hepatocyte secretes both proteins and bile concomitantly at its basolateral and apical domains, respectively. In this Beyond the Cell review, we will detail these central features of the hepatocyte and highlight how membrane transport processes play a key role in healthy liver function and how they are affected by disease.

Original languageEnglish (US)
Pages (from-to)2096-2112
Number of pages17
JournalThe Journal of cell biology
Volume218
Issue number7
DOIs
StatePublished - Jul 1 2019

Fingerprint

Cell Biology
Hepatocytes
Membranes
Liver
Bile
Proteins
Digestion
Epithelial Cells
Lipids
Food
Brain

ASJC Scopus subject areas

  • Cell Biology

Cite this

The cell biology of the hepatocyte : A membrane trafficking machine. / Schulze, Ryan J.; Schott, Micah B.; Casey, Carol A.; Tuma, Pamela L.; Mc Niven, Mark A.

In: The Journal of cell biology, Vol. 218, No. 7, 01.07.2019, p. 2096-2112.

Research output: Contribution to journalReview article

Schulze, Ryan J. ; Schott, Micah B. ; Casey, Carol A. ; Tuma, Pamela L. ; Mc Niven, Mark A. / The cell biology of the hepatocyte : A membrane trafficking machine. In: The Journal of cell biology. 2019 ; Vol. 218, No. 7. pp. 2096-2112.
@article{9a845b52c781489782522bb5ca9c0932,
title = "The cell biology of the hepatocyte: A membrane trafficking machine",
abstract = "The liver performs numerous vital functions, including the detoxification of blood before access to the brain while simultaneously secreting and internalizing scores of proteins and lipids to maintain appropriate blood chemistry. Furthermore, the liver also synthesizes and secretes bile to enable the digestion of food. These diverse attributes are all performed by hepatocytes, the parenchymal cells of the liver. As predicted, these cells possess a remarkably well-developed and complex membrane trafficking machinery that is dedicated to moving specific cargos to their correct cellular locations. Importantly, while most epithelial cells secrete nascent proteins directionally toward a single lumen, the hepatocyte secretes both proteins and bile concomitantly at its basolateral and apical domains, respectively. In this Beyond the Cell review, we will detail these central features of the hepatocyte and highlight how membrane transport processes play a key role in healthy liver function and how they are affected by disease.",
author = "Schulze, {Ryan J.} and Schott, {Micah B.} and Casey, {Carol A.} and Tuma, {Pamela L.} and {Mc Niven}, {Mark A}",
year = "2019",
month = "7",
day = "1",
doi = "10.1083/jcb.201903090",
language = "English (US)",
volume = "218",
pages = "2096--2112",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "7",

}

TY - JOUR

T1 - The cell biology of the hepatocyte

T2 - A membrane trafficking machine

AU - Schulze, Ryan J.

AU - Schott, Micah B.

AU - Casey, Carol A.

AU - Tuma, Pamela L.

AU - Mc Niven, Mark A

PY - 2019/7/1

Y1 - 2019/7/1

N2 - The liver performs numerous vital functions, including the detoxification of blood before access to the brain while simultaneously secreting and internalizing scores of proteins and lipids to maintain appropriate blood chemistry. Furthermore, the liver also synthesizes and secretes bile to enable the digestion of food. These diverse attributes are all performed by hepatocytes, the parenchymal cells of the liver. As predicted, these cells possess a remarkably well-developed and complex membrane trafficking machinery that is dedicated to moving specific cargos to their correct cellular locations. Importantly, while most epithelial cells secrete nascent proteins directionally toward a single lumen, the hepatocyte secretes both proteins and bile concomitantly at its basolateral and apical domains, respectively. In this Beyond the Cell review, we will detail these central features of the hepatocyte and highlight how membrane transport processes play a key role in healthy liver function and how they are affected by disease.

AB - The liver performs numerous vital functions, including the detoxification of blood before access to the brain while simultaneously secreting and internalizing scores of proteins and lipids to maintain appropriate blood chemistry. Furthermore, the liver also synthesizes and secretes bile to enable the digestion of food. These diverse attributes are all performed by hepatocytes, the parenchymal cells of the liver. As predicted, these cells possess a remarkably well-developed and complex membrane trafficking machinery that is dedicated to moving specific cargos to their correct cellular locations. Importantly, while most epithelial cells secrete nascent proteins directionally toward a single lumen, the hepatocyte secretes both proteins and bile concomitantly at its basolateral and apical domains, respectively. In this Beyond the Cell review, we will detail these central features of the hepatocyte and highlight how membrane transport processes play a key role in healthy liver function and how they are affected by disease.

UR - http://www.scopus.com/inward/record.url?scp=85069266476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069266476&partnerID=8YFLogxK

U2 - 10.1083/jcb.201903090

DO - 10.1083/jcb.201903090

M3 - Review article

C2 - 31201265

AN - SCOPUS:85069266476

VL - 218

SP - 2096

EP - 2112

JO - Journal of Cell Biology

JF - Journal of Cell Biology

SN - 0021-9525

IS - 7

ER -