The catalytic formation of peptide bonds with carbohydrate protein conjugates of proteases [CPC(proteases)]

Peng Wang, Tara G. Hill, Mark D. Bednarski, Matthew R Callstrom

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

This paper describes the use of carbohydrate protein conjugates of proteases [CPC(proteases)] for the catalytic formation of peptide bonds. We have found that CPC(proteases) are stable in organic solvents and perform at truly catalytic levels and have demonstrated a basis set of transformations that allow for convergent peptide synthesis.

Original languageEnglish (US)
Pages (from-to)6827-6830
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number47
DOIs
StatePublished - Nov 18 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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