The catalytic formation of peptide bonds with carbohydrate protein conjugates of proteases [CPC(proteases)]

Peng Wang, Tara G. Hill, Mark D. Bednarski, Matthew R Callstrom

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

This paper describes the use of carbohydrate protein conjugates of proteases [CPC(proteases)] for the catalytic formation of peptide bonds. We have found that CPC(proteases) are stable in organic solvents and perform at truly catalytic levels and have demonstrated a basis set of transformations that allow for convergent peptide synthesis.

Original languageEnglish (US)
Pages (from-to)6827-6830
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number47
DOIs
StatePublished - Nov 18 1991
Externally publishedYes

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Peptide Hydrolases
Carbohydrates
Peptides
Organic solvents
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

The catalytic formation of peptide bonds with carbohydrate protein conjugates of proteases [CPC(proteases)]. / Wang, Peng; Hill, Tara G.; Bednarski, Mark D.; Callstrom, Matthew R.

In: Tetrahedron Letters, Vol. 32, No. 47, 18.11.1991, p. 6827-6830.

Research output: Contribution to journal › Article

Wang, P, Hill, TG, Bednarski, MD & Callstrom, MR 1991, 'The catalytic formation of peptide bonds with carbohydrate protein conjugates of proteases [CPC(proteases)]', Tetrahedron Letters, vol. 32, no. 47, pp. 6827-6830. https://doi.org/10.1016/0040-4039(91)80417-5
Wang P, Hill TG, Bednarski MD, Callstrom MR. The catalytic formation of peptide bonds with carbohydrate protein conjugates of proteases [CPC(proteases)]. Tetrahedron Letters. 1991 Nov 18;32(47):6827-6830. https://doi.org/10.1016/0040-4039(91)80417-5
Wang, Peng ; Hill, Tara G. ; Bednarski, Mark D. ; Callstrom, Matthew R. / The catalytic formation of peptide bonds with carbohydrate protein conjugates of proteases [CPC(proteases)]. In: Tetrahedron Letters. 1991 ; Vol. 32, No. 47. pp. 6827-6830.
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