The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid β peptide: Implications for Alzheimer disease pathogenesis

Medicine & Life Sciences

• Insulysin 100%
• Amyloid 61%
• Catalytic Domain 58%
• Alzheimer Disease 50%
• Peptides 41%
• Insulin 14%
• Dissociative Disorders 9%
• Brain 7%
• Proteolysis 6%
• Digestion 6%
• Mass Spectrometry 6%
• Peptide Hydrolases 6%
• Gels 5%
• Molecular Biology 5%
• Binding Sites 5%
• Type 2 Diabetes Mellitus 5%
• Kinetics 5%

Chemical Compounds

• Insulin Derivative 65%
• Peptide 37%
• Limited Proteolysis 27%
• Clearance 23%
• Denaturation 19%
• Dissociation 15%
• Mass Spectrometry 14%
• Gel 13%