Abstract
A theoretical study was performed to determine the accuracy and repeatability of multiple one-dimensional pulse sequences in the quantification of glutamine concentration at 3T. Variable repeatability (12% to>50%) and significant absolute error (-50% to +70%) were noted for the eight pulse sequences considered. Data acquired in vivo using three of the pulse sequences used for simulation matched the predicted repeatability well; among the pulse sequences considered, point-resolved spectroscopy (TE=80ms) offered minimal error and acceptable repeatability (12%) for brain glutamine measurements. Following correction for the expected bias of each pulse sequence, consistent glutamine measurements, in the 1-mM range, were reported with the three sequences. An explanation for the mismatch between in vivo 1H MRS and in vitro 13C/1H MRS at high field was attempted.
Original language | English (US) |
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Pages (from-to) | 529-535 |
Number of pages | 7 |
Journal | NMR in Biomedicine |
Volume | 24 |
Issue number | 5 |
DOIs | |
State | Published - Jun 2011 |
Keywords
- 3 T
- Glutamine
- MRS
- Simulations
- Spectroscopy
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Spectroscopy