The case of the missing glutamine

Ileana Hancu, John Port

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


A theoretical study was performed to determine the accuracy and repeatability of multiple one-dimensional pulse sequences in the quantification of glutamine concentration at 3T. Variable repeatability (12% to>50%) and significant absolute error (-50% to +70%) were noted for the eight pulse sequences considered. Data acquired in vivo using three of the pulse sequences used for simulation matched the predicted repeatability well; among the pulse sequences considered, point-resolved spectroscopy (TE=80ms) offered minimal error and acceptable repeatability (12%) for brain glutamine measurements. Following correction for the expected bias of each pulse sequence, consistent glutamine measurements, in the 1-mM range, were reported with the three sequences. An explanation for the mismatch between in vivo 1H MRS and in vitro 13C/1H MRS at high field was attempted.

Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalNMR in Biomedicine
Issue number5
StatePublished - Jun 2011


  • 3 T
  • Glutamine
  • MRS
  • Simulations
  • Spectroscopy

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


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