The butterfly effect on glioblastoma: is volumetric extent of resection more effective than biopsy for these tumors?

Kaisorn L. Chaichana, Ignacio Jusue-Torres, Ana Maria Lemos, Aaron Gokaslan, Eibar Ernesto Cabrera-Aldana, Ahmed Ashary, Alessandro Olivi, Alfredo Quinones-Hinojosa

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A subset of patients with glioblastoma (GBM) have butterfly GBM (bGBM) that involve both cerebral hemispheres by crossing the corpus callosum. The prognoses, as well as the effectiveness of surgery and adjuvant therapy, are unclear because studies are few and limited. The goals of this study were to: (1) determine if bGBM have worse outcomes than patients with non-bGBM, (2) determine if surgery is more effective than biopsy, and (3) identify factors independently associated with improved outcomes for these patients. Adult patients who underwent surgery for a newly diagnosed primary GBM at an academic tertiary-care institution between 2007 and 2012 were retrospectively reviewed and tumors were volumetrically measured. Of the 336 patients with newly diagnosed GBM who were operated on, 48 (14 %) presented with bGBM, where 29 (60 %) and 19 (40 %) underwent surgical resection and biopsy, respectively. In multivariate analysis, a bGBM was independently associated with poorer survival [HR (95 % CI) 1.848 (1.250–2.685), p < 0.003]. In matched-pair analysis, patients who underwent surgical resection had improved median survival than biopsy patients (7.0 vs. 3.5 months, p = 0.03). In multivariate analysis, increasing percent resection [HR (95 % CI) 0.987 (0.977–0.997), p = 0.01], radiation [HR (95 % CI) 0.431 (0.225–0.812), p = 0.009], and temozolomide [HR (95 % CI) 0.413 (0.212–0. 784), p = 0.007] were each independently associated with prolonged survival among patients with bGBM. This present study shows that while patients with bGBM have poorer prognoses compared to non-bGBM, these patients can also benefit from aggressive treatments including debulking surgery, maximal safe surgical resection, temozolomide chemotherapy, and radiation therapy.

Original languageEnglish (US)
Pages (from-to)625-634
Number of pages10
JournalJournal of Neuro-Oncology
Volume120
Issue number3
DOIs
StatePublished - Nov 18 2014
Externally publishedYes

Fingerprint

Butterflies
Glioblastoma
Biopsy
temozolomide
Neoplasms
Survival
Multivariate Analysis
Matched-Pair Analysis
Corpus Callosum
Cerebrum
Tertiary Healthcare
Radiotherapy
Radiation
Drug Therapy

Keywords

  • Butterfly
  • Corpus callosum
  • GBM
  • Glioblastoma
  • Radiation
  • Survival
  • Temozolomide

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology
  • Medicine(all)

Cite this

The butterfly effect on glioblastoma : is volumetric extent of resection more effective than biopsy for these tumors? / Chaichana, Kaisorn L.; Jusue-Torres, Ignacio; Lemos, Ana Maria; Gokaslan, Aaron; Cabrera-Aldana, Eibar Ernesto; Ashary, Ahmed; Olivi, Alessandro; Quinones-Hinojosa, Alfredo.

In: Journal of Neuro-Oncology, Vol. 120, No. 3, 18.11.2014, p. 625-634.

Research output: Contribution to journalArticle

Chaichana, KL, Jusue-Torres, I, Lemos, AM, Gokaslan, A, Cabrera-Aldana, EE, Ashary, A, Olivi, A & Quinones-Hinojosa, A 2014, 'The butterfly effect on glioblastoma: is volumetric extent of resection more effective than biopsy for these tumors?', Journal of Neuro-Oncology, vol. 120, no. 3, pp. 625-634. https://doi.org/10.1007/s11060-014-1597-9
Chaichana, Kaisorn L. ; Jusue-Torres, Ignacio ; Lemos, Ana Maria ; Gokaslan, Aaron ; Cabrera-Aldana, Eibar Ernesto ; Ashary, Ahmed ; Olivi, Alessandro ; Quinones-Hinojosa, Alfredo. / The butterfly effect on glioblastoma : is volumetric extent of resection more effective than biopsy for these tumors?. In: Journal of Neuro-Oncology. 2014 ; Vol. 120, No. 3. pp. 625-634.
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abstract = "A subset of patients with glioblastoma (GBM) have butterfly GBM (bGBM) that involve both cerebral hemispheres by crossing the corpus callosum. The prognoses, as well as the effectiveness of surgery and adjuvant therapy, are unclear because studies are few and limited. The goals of this study were to: (1) determine if bGBM have worse outcomes than patients with non-bGBM, (2) determine if surgery is more effective than biopsy, and (3) identify factors independently associated with improved outcomes for these patients. Adult patients who underwent surgery for a newly diagnosed primary GBM at an academic tertiary-care institution between 2007 and 2012 were retrospectively reviewed and tumors were volumetrically measured. Of the 336 patients with newly diagnosed GBM who were operated on, 48 (14 {\%}) presented with bGBM, where 29 (60 {\%}) and 19 (40 {\%}) underwent surgical resection and biopsy, respectively. In multivariate analysis, a bGBM was independently associated with poorer survival [HR (95 {\%} CI) 1.848 (1.250–2.685), p < 0.003]. In matched-pair analysis, patients who underwent surgical resection had improved median survival than biopsy patients (7.0 vs. 3.5 months, p = 0.03). In multivariate analysis, increasing percent resection [HR (95 {\%} CI) 0.987 (0.977–0.997), p = 0.01], radiation [HR (95 {\%} CI) 0.431 (0.225–0.812), p = 0.009], and temozolomide [HR (95 {\%} CI) 0.413 (0.212–0. 784), p = 0.007] were each independently associated with prolonged survival among patients with bGBM. This present study shows that while patients with bGBM have poorer prognoses compared to non-bGBM, these patients can also benefit from aggressive treatments including debulking surgery, maximal safe surgical resection, temozolomide chemotherapy, and radiation therapy.",
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