The brain-machine interface: Nanotechniques for improving brain electrochemical monitoring and modulating

R. Andrews; K. Bennet; Su-Youne Chang; J. Koehne; Kendall H Lee; M. Marsh; M. Meyyappan; E. Rand

The brain-machine interface: Nanotechniques for improving brain electrochemical monitoring and modulating

R. Andrews, K. Bennet, Su-Youne Chang, J. Koehne, Kendall H Lee, M. Marsh, M. Meyyappan, E. Rand

Neurosurgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Present neuromodulation (e.g. deep brain stimulation-DBS) has inefficient charge transfer from electrode to brain tissue, and lacks both neurotransmitter monitoring and feedback-guided stimulation. Six 50 × 20 μm carbon nano-fiber (CNF) "pads" on an electrode 1/10 the diameter of a DBS electrode can either stimulate or record electrical activity or monitor a neurotransmitter level. Novel fast-scan cyclic voltammetry (FSCV) methods allow continuous recording of two neurotransmitters. Conducting polymers on CNF electrodes reduce impedance and increase capacitance orders of magnitude above platinum electrodes. CNF electrodes detect concentration changes in either of two neurotransmitters, e.g. dopamine and serotonin, in ascorbic acid (ubiquitous in brain), unlike standard FSCV electrodes. A Bluetooth wireless system allows remote monitoring of both electrical and chemical brain activity with precise spatial-temporal resolution, increasing understanding of brain function - both normal and disordered.

Original language	English (US)
Title of host publication	Advanced Materials - TechConnect Briefs 2016
Publisher	TechConnect
Pages	61-64
Number of pages	4
Volume	1
ISBN (Electronic)	9780997511703
State	Published - 2016
Event	10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference - Washington, United States Duration: May 22 2016 → May 25 2016

Other

Other	10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference
Country/Territory	United States
City	Washington
Period	5/22/16 → 5/25/16

Keywords

Brain-machine interface
Deep brain stimulation
Nanoelectrodes
Neuromodulation
Neurotransmitters

ASJC Scopus subject areas

Fluid Flow and Transfer Processes
Biotechnology
Surfaces, Coatings and Films
Fuel Technology

Cite this

Andrews, R, Bennet, K, Chang, S-Y, Koehne, J, Lee, KH, Marsh, M, Meyyappan, M & Rand, E 2016, The brain-machine interface: Nanotechniques for improving brain electrochemical monitoring and modulating. in Advanced Materials - TechConnect Briefs 2016. vol. 1, TechConnect, pp. 61-64, 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference, Washington, United States, 5/22/16.

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abstract = "Present neuromodulation (e.g. deep brain stimulation-DBS) has inefficient charge transfer from electrode to brain tissue, and lacks both neurotransmitter monitoring and feedback-guided stimulation. Six 50 × 20 μm carbon nano-fiber (CNF) {"}pads{"} on an electrode 1/10 the diameter of a DBS electrode can either stimulate or record electrical activity or monitor a neurotransmitter level. Novel fast-scan cyclic voltammetry (FSCV) methods allow continuous recording of two neurotransmitters. Conducting polymers on CNF electrodes reduce impedance and increase capacitance orders of magnitude above platinum electrodes. CNF electrodes detect concentration changes in either of two neurotransmitters, e.g. dopamine and serotonin, in ascorbic acid (ubiquitous in brain), unlike standard FSCV electrodes. A Bluetooth wireless system allows remote monitoring of both electrical and chemical brain activity with precise spatial-temporal resolution, increasing understanding of brain function - both normal and disordered.",

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author = "R. Andrews and K. Bennet and Su-Youne Chang and J. Koehne and Lee, {Kendall H} and M. Marsh and M. Meyyappan and E. Rand",

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AU - Bennet, K.

AU - Chang, Su-Youne

AU - Koehne, J.

AU - Lee, Kendall H

AU - Marsh, M.

AU - Meyyappan, M.

AU - Rand, E.

PY - 2016

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N2 - Present neuromodulation (e.g. deep brain stimulation-DBS) has inefficient charge transfer from electrode to brain tissue, and lacks both neurotransmitter monitoring and feedback-guided stimulation. Six 50 × 20 μm carbon nano-fiber (CNF) "pads" on an electrode 1/10 the diameter of a DBS electrode can either stimulate or record electrical activity or monitor a neurotransmitter level. Novel fast-scan cyclic voltammetry (FSCV) methods allow continuous recording of two neurotransmitters. Conducting polymers on CNF electrodes reduce impedance and increase capacitance orders of magnitude above platinum electrodes. CNF electrodes detect concentration changes in either of two neurotransmitters, e.g. dopamine and serotonin, in ascorbic acid (ubiquitous in brain), unlike standard FSCV electrodes. A Bluetooth wireless system allows remote monitoring of both electrical and chemical brain activity with precise spatial-temporal resolution, increasing understanding of brain function - both normal and disordered.

AB - Present neuromodulation (e.g. deep brain stimulation-DBS) has inefficient charge transfer from electrode to brain tissue, and lacks both neurotransmitter monitoring and feedback-guided stimulation. Six 50 × 20 μm carbon nano-fiber (CNF) "pads" on an electrode 1/10 the diameter of a DBS electrode can either stimulate or record electrical activity or monitor a neurotransmitter level. Novel fast-scan cyclic voltammetry (FSCV) methods allow continuous recording of two neurotransmitters. Conducting polymers on CNF electrodes reduce impedance and increase capacitance orders of magnitude above platinum electrodes. CNF electrodes detect concentration changes in either of two neurotransmitters, e.g. dopamine and serotonin, in ascorbic acid (ubiquitous in brain), unlike standard FSCV electrodes. A Bluetooth wireless system allows remote monitoring of both electrical and chemical brain activity with precise spatial-temporal resolution, increasing understanding of brain function - both normal and disordered.

KW - Brain-machine interface

KW - Deep brain stimulation

KW - Nanoelectrodes

KW - Neuromodulation

KW - Neurotransmitters

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BT - Advanced Materials - TechConnect Briefs 2016

PB - TechConnect

Y2 - 22 May 2016 through 25 May 2016

ER -

The brain-machine interface: Nanotechniques for improving brain electrochemical monitoring and modulating

Abstract

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Keywords

ASJC Scopus subject areas

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