The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

Shahrzad Jalali; Stephen Maxted Ansell

doi:10.1016/j.hoc.2018.05.005

The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

Shahrzad Jalali, Stephen Maxted Ansell

Hematology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment. This article highlights the available data regarding the interaction of WM cells with both the cellular and noncellular compartments of the BM microenvironment and discusses how the BM promotes malignant cell growth and increases IgM production in this disease.

Original language	English (US)
Journal	Hematology/Oncology Clinics of North America
DOIs	https://doi.org/10.1016/j.hoc.2018.05.005
State	Accepted/In press - Jan 1 2018

Keywords

Angiogenesis
Bone marrow niche
Cytokines
Homing
Immune cells
Microenvironment
Waldenström macroglobulinemia

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2018.05.005

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title = "The Bone Marrow Microenvironment in Waldenstr{\"o}m Macroglobulinemia",

abstract = "Waldenstr{\"o}m macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment. This article highlights the available data regarding the interaction of WM cells with both the cellular and noncellular compartments of the BM microenvironment and discusses how the BM promotes malignant cell growth and increases IgM production in this disease.",

keywords = "Angiogenesis, Bone marrow niche, Cytokines, Homing, Immune cells, Microenvironment, Waldenstr{\"o}m macroglobulinemia",

author = "Shahrzad Jalali and Ansell, {Stephen Maxted}",

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day = "1",

doi = "10.1016/j.hoc.2018.05.005",

language = "English (US)",

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T1 - The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

AU - Jalali, Shahrzad

AU - Ansell, Stephen Maxted

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment. This article highlights the available data regarding the interaction of WM cells with both the cellular and noncellular compartments of the BM microenvironment and discusses how the BM promotes malignant cell growth and increases IgM production in this disease.

AB - Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment. This article highlights the available data regarding the interaction of WM cells with both the cellular and noncellular compartments of the BM microenvironment and discusses how the BM promotes malignant cell growth and increases IgM production in this disease.

KW - Angiogenesis

KW - Bone marrow niche

KW - Cytokines

KW - Homing

KW - Immune cells

KW - Microenvironment

KW - Waldenström macroglobulinemia

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DO - 10.1016/j.hoc.2018.05.005

M3 - Article

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AN - SCOPUS:85050369372

SN - 0889-8588

JO - Hematology/Oncology Clinics of North America

JF - Hematology/Oncology Clinics of North America

ER -

The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

Abstract

Keywords

ASJC Scopus subject areas

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