The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

Shahrzad Jalali; Stephen M. Ansell

doi:10.1016/j.hoc.2018.05.005

The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

Shahrzad Jalali, Stephen M. Ansell

Hematology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment. This article highlights the available data regarding the interaction of WM cells with both the cellular and noncellular compartments of the BM microenvironment and discusses how the BM promotes malignant cell growth and increases IgM production in this disease.

Original language	English (US)
Pages (from-to)	777-786
Number of pages	10
Journal	Hematology/Oncology Clinics of North America
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/j.hoc.2018.05.005
State	Published - Oct 2018

Keywords

Angiogenesis
Bone marrow niche
Cytokines
Homing
Immune cells
Microenvironment
Waldenström macroglobulinemia

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2018.05.005

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title = "The Bone Marrow Microenvironment in Waldenstr{\"o}m Macroglobulinemia",

abstract = "Waldenstr{\"o}m macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment. This article highlights the available data regarding the interaction of WM cells with both the cellular and noncellular compartments of the BM microenvironment and discusses how the BM promotes malignant cell growth and increases IgM production in this disease.",

keywords = "Angiogenesis, Bone marrow niche, Cytokines, Homing, Immune cells, Microenvironment, Waldenstr{\"o}m macroglobulinemia",

author = "Shahrzad Jalali and Ansell, {Stephen M.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = oct,

doi = "10.1016/j.hoc.2018.05.005",

language = "English (US)",

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journal = "Hematology/Oncology Clinics of North America",

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TY - JOUR

T1 - The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

AU - Jalali, Shahrzad

AU - Ansell, Stephen M.

PY - 2018/10

Y1 - 2018/10

N2 - Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment. This article highlights the available data regarding the interaction of WM cells with both the cellular and noncellular compartments of the BM microenvironment and discusses how the BM promotes malignant cell growth and increases IgM production in this disease.

AB - Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment. This article highlights the available data regarding the interaction of WM cells with both the cellular and noncellular compartments of the BM microenvironment and discusses how the BM promotes malignant cell growth and increases IgM production in this disease.

KW - Angiogenesis

KW - Bone marrow niche

KW - Cytokines

KW - Homing

KW - Immune cells

KW - Microenvironment

KW - Waldenström macroglobulinemia

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U2 - 10.1016/j.hoc.2018.05.005

DO - 10.1016/j.hoc.2018.05.005

M3 - Review article

C2 - 30190017

AN - SCOPUS:85050369372

SN - 0889-8588

VL - 32

SP - 777

EP - 786

JO - Hematology/Oncology Clinics of North America

JF - Hematology/Oncology Clinics of North America

IS - 5

ER -

The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

Abstract

Keywords

ASJC Scopus subject areas

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